Radioprotective Potential of Nutraceuticals and their Underlying Mechanism of Action

Shabnoor Iqbal, Muhammad Ajmal Shah, Azhar Rasul, Malik Saadullah, Sobia Tabassum, Shujat Ali, Muhammad Zafar, Haji Muhammad, Md Sahab Uddin, Gaber El Saber Batiha, Celia Vargas-De-la-cruz

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Radiations are an efficient treatment modality in cancer therapy. Besides the treatment effects of radiations, the ionizing radiations interact with biological systems and generate reactive oxygen species that interfere with the normal cellular process. Previous investigations have been conducted only on few synthetic radioprotectors, mainly owing to some limiting effects. The nutraceuticals act as efficient radioprotectors to protect the tissues from the deleterious effects of radiation. The main radioprotection mechanism of nutraceuticals is the scavenging of free radicals while other strategies involve modulation of signaling transduction pathways like MAPK (JNK, ERK1/2, ERK5, and P38), NF-kB, cytokines, and their protein regulatory gene expression. The current review is focused on the radioprotective effects of nutraceuticals including vitamin E,-C, organosulphur compounds, phenylpropanoids, and polysaccharides. These natural entities protect against radiation-induced DNA damage. The review mainly entails the antioxidant perspective and radioprotective molecular mechanism of nutraceuticals, DNA repair pathway, anti-inflammation, immunomodulatory effects and regeneration of hematopoietic cells.

Original languageEnglish
Pages (from-to)40-52
Number of pages13
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume22
Issue number1
DOIs
StatePublished - 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 Bentham Science Publishers.

Keywords

  • Anticancer
  • Antioxidants
  • Chemoprevention
  • Natural products
  • Nutraceuticals
  • Radioprotector

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