Reducción en la infección por VHB y VHD en dos poblaciones indígenas de la Amazonia peruana después de la vacunación contra la hepatitis B

Translated title of the contribution: Reduction of HBV and HDV infection in two indigenous peoples of Peruvian Amazon after the vaccination against hepatitis B

Cesar Augusto Cabezas Sanchez, Omar Trujillo, Johanna Balbuena, Manuel Terrazas, Carlos Manrique-de Lara, Luis Marín, Max Carlos Ramírez-Soto

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective. To determine the outcome of the vaccination against hepatitis, we determined the prevalence of hepatitis B virus (HBV) and hepatitis D virus (HDV) infections, eight years after introduction of the vaccination. Materials and methods. A cross-sectional study was performed in 2 944 participants of 67 Kandozi and Chapra indigenous peoples in April 2010. Serological screening for hepatitis B surface antigen (HBsAg), antibody anti-HBc IgM and IgG, antibody anti-HBs and anti-HDV were determined by ELISA tests. Results. The prevalence rates of HBsAg, anti-HBc total, anti-HBs ≥10 mlUI/ml and anti-HDV were 2.3, 39.13, 50.95 and 2.11%, respectively. The prevalence rate of HBsAg in children <11 years was 0%. Among carriers of HBsAg, the prevalence rates of HDV and acute HBV infections were 2.11% (all were >14 years) and 11.94%, respectively. HBsAg and anti-HBc total were associated with individuals ≥10 years (p<0.001). Conclusions. These findings show the elimination of HBV carriers in children <11 years, eight years following introduction of the vaccination against HBV.

Translated title of the contributionReduction of HBV and HDV infection in two indigenous peoples of Peruvian Amazon after the vaccination against hepatitis B
Original languageSpanish
Article number11128
Pages (from-to)237-245
Number of pages9
JournalSalud Publica de Mexico
Volume62
Issue number3
DOIs
StatePublished - 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020, Instituto Nacional de Salud Publica.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

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