Relationship between care model and disease activity states and health-related quality of life in systemic lupus erythematosus patients

Luciana Perea-Seoane; Estefania Agapito-Vera; Rocío V. Gamboa-Cardenas; Geny Guzmán-Sánchez; Victor Román Pimentel-Quiroz; Cristina Reategui-Sokolova; Mariela Medina; Claudia Elera-Fitzcarrald; Erika Noriega; Zoila Rodriguez-Bellido; Cesar Pastor-Asurza; Risto Perich-Campos; Graciela S. Alarcón; Manuel F. Ugarte-Gil

doi:10.1177/09612033211063798

Relationship between care model and disease activity states and health-related quality of life in systemic lupus erythematosus patients

Luciana Perea-Seoane, Estefania Agapito-Vera, Rocío V. Gamboa-Cardenas, Geny Guzmán-Sánchez, Victor Román Pimentel-Quiroz, Cristina Reategui-Sokolova, Mariela Medina, Claudia Elera-Fitzcarrald, Erika Noriega, Zoila Rodriguez-Bellido, Cesar Pastor-Asurza, Risto Perich-Campos, Graciela S. Alarcón, Manuel F. Ugarte-Gil

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Abstract

Objective: To assess whether the care model (comprehensive vs regular) has any impact on the clinical outcomes of systemic lupus erythematosus patients. Methods: Between August 2019 and January 2020, we evaluated SLE patients being cared for at two Peruvian hospitals to define the impact of care model on disease activity state and health-related quality of life (HRQoL). Disease activity was ascertained with the SLEDAI-2K and the Physician Global Assessment (PGA) which allows to define Lupus Low Disease Activity State (LLDAS) and Remission. HRQoL was measured with the LupusQoL. The association between care model and disease activity (Remission and LLDAS) state was examined using a binary logistic regression model. The association with HRQoL was examined with a linear regression model. All multivariable analyses were adjusted for possible confounders. Results: 266 SLE patients were included, 227 from the comprehensive care model and 39 from the regular care model. The regular care model was associated with a lower probability of achieving remission (OR 0.381; CI: 95% 0.163–0.887) and LLDAS (OR 0.363; CI: 95% 0.157–0.835). Regular care was associated with a better HRQoL in two domains (pain and emotional health). We found no association between the care model and the other HRQoL domains. Conclusion: A comprehensive care model was associated with the probability of achieving remission and LLDAS but had no apparent impact on the patients’ HRQoL.

Original language	English
Pages (from-to)	110-115
Number of pages	6
Journal	Lupus
Volume	31
Issue number	1
DOIs	https://doi.org/10.1177/09612033211063798
State	Published - Jan 2022

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The Almenara Lupus Cohort was partially supported by institutional grants from EsSalud (1483-GCGP-ESSALUD-2013, 1733-GCGP-ESSALUD-2014, and the 2015 Kaelin Prize 04-IETSI-ESALUD-2016), from the Pan American League of Associations for Rheumatology (PANLAR) (2015 PANLAR Prize and the 2018 H. Ralph Schumacher MD/JCR/PANLAR Prize), and from the Fundación Instituto Hipólito Unanue and an irrestricted grant from Janssen.

Publisher Copyright:
© The Author(s) 2021.

Keywords

Systemic lupus erythematosus
care model
damage
health-related quality of care
low lupus disease activity state
remission

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Perea-Seoane, L., Agapito-Vera, E., Gamboa-Cardenas, R. V., Guzmán-Sánchez, G., Pimentel-Quiroz, V. R., Reategui-Sokolova, C., Medina, M., Elera-Fitzcarrald, C., Noriega, E., Rodriguez-Bellido, Z., Pastor-Asurza, C., Perich-Campos, R., Alarcón, G. S., & Ugarte-Gil, M. F. (2022). Relationship between care model and disease activity states and health-related quality of life in systemic lupus erythematosus patients. Lupus, 31(1), 110-115. https://doi.org/10.1177/09612033211063798

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title = "Relationship between care model and disease activity states and health-related quality of life in systemic lupus erythematosus patients",

abstract = "Objective: To assess whether the care model (comprehensive vs regular) has any impact on the clinical outcomes of systemic lupus erythematosus patients. Methods: Between August 2019 and January 2020, we evaluated SLE patients being cared for at two Peruvian hospitals to define the impact of care model on disease activity state and health-related quality of life (HRQoL). Disease activity was ascertained with the SLEDAI-2K and the Physician Global Assessment (PGA) which allows to define Lupus Low Disease Activity State (LLDAS) and Remission. HRQoL was measured with the LupusQoL. The association between care model and disease activity (Remission and LLDAS) state was examined using a binary logistic regression model. The association with HRQoL was examined with a linear regression model. All multivariable analyses were adjusted for possible confounders. Results: 266 SLE patients were included, 227 from the comprehensive care model and 39 from the regular care model. The regular care model was associated with a lower probability of achieving remission (OR 0.381; CI: 95% 0.163–0.887) and LLDAS (OR 0.363; CI: 95% 0.157–0.835). Regular care was associated with a better HRQoL in two domains (pain and emotional health). We found no association between the care model and the other HRQoL domains. Conclusion: A comprehensive care model was associated with the probability of achieving remission and LLDAS but had no apparent impact on the patients{\textquoteright} HRQoL.",

keywords = "Systemic lupus erythematosus, care model, damage, health-related quality of care, low lupus disease activity state, remission",

author = "Luciana Perea-Seoane and Estefania Agapito-Vera and Gamboa-Cardenas, {Roc{\'i}o V.} and Geny Guzm{\'a}n-S{\'a}nchez and Pimentel-Quiroz, {Victor Rom{\'a}n} and Cristina Reategui-Sokolova and Mariela Medina and Claudia Elera-Fitzcarrald and Erika Noriega and Zoila Rodriguez-Bellido and Cesar Pastor-Asurza and Risto Perich-Campos and Alarc{\'o}n, {Graciela S.} and Ugarte-Gil, {Manuel F.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2021.",

year = "2022",

month = jan,

doi = "10.1177/09612033211063798",

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volume = "31",

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Perea-Seoane, L, Agapito-Vera, E, Gamboa-Cardenas, RV, Guzmán-Sánchez, G, Pimentel-Quiroz, VR, Reategui-Sokolova, C, Medina, M, Elera-Fitzcarrald, C, Noriega, E, Rodriguez-Bellido, Z, Pastor-Asurza, C, Perich-Campos, R, Alarcón, GS & Ugarte-Gil, MF 2022, 'Relationship between care model and disease activity states and health-related quality of life in systemic lupus erythematosus patients', Lupus, vol. 31, no. 1, pp. 110-115. https://doi.org/10.1177/09612033211063798

TY - JOUR

T1 - Relationship between care model and disease activity states and health-related quality of life in systemic lupus erythematosus patients

AU - Perea-Seoane, Luciana

AU - Agapito-Vera, Estefania

AU - Gamboa-Cardenas, Rocío V.

AU - Guzmán-Sánchez, Geny

AU - Pimentel-Quiroz, Victor Román

AU - Reategui-Sokolova, Cristina

AU - Medina, Mariela

AU - Elera-Fitzcarrald, Claudia

AU - Noriega, Erika

AU - Rodriguez-Bellido, Zoila

AU - Pastor-Asurza, Cesar

AU - Perich-Campos, Risto

AU - Alarcón, Graciela S.

AU - Ugarte-Gil, Manuel F.

PY - 2022/1

Y1 - 2022/1

N2 - Objective: To assess whether the care model (comprehensive vs regular) has any impact on the clinical outcomes of systemic lupus erythematosus patients. Methods: Between August 2019 and January 2020, we evaluated SLE patients being cared for at two Peruvian hospitals to define the impact of care model on disease activity state and health-related quality of life (HRQoL). Disease activity was ascertained with the SLEDAI-2K and the Physician Global Assessment (PGA) which allows to define Lupus Low Disease Activity State (LLDAS) and Remission. HRQoL was measured with the LupusQoL. The association between care model and disease activity (Remission and LLDAS) state was examined using a binary logistic regression model. The association with HRQoL was examined with a linear regression model. All multivariable analyses were adjusted for possible confounders. Results: 266 SLE patients were included, 227 from the comprehensive care model and 39 from the regular care model. The regular care model was associated with a lower probability of achieving remission (OR 0.381; CI: 95% 0.163–0.887) and LLDAS (OR 0.363; CI: 95% 0.157–0.835). Regular care was associated with a better HRQoL in two domains (pain and emotional health). We found no association between the care model and the other HRQoL domains. Conclusion: A comprehensive care model was associated with the probability of achieving remission and LLDAS but had no apparent impact on the patients’ HRQoL.

AB - Objective: To assess whether the care model (comprehensive vs regular) has any impact on the clinical outcomes of systemic lupus erythematosus patients. Methods: Between August 2019 and January 2020, we evaluated SLE patients being cared for at two Peruvian hospitals to define the impact of care model on disease activity state and health-related quality of life (HRQoL). Disease activity was ascertained with the SLEDAI-2K and the Physician Global Assessment (PGA) which allows to define Lupus Low Disease Activity State (LLDAS) and Remission. HRQoL was measured with the LupusQoL. The association between care model and disease activity (Remission and LLDAS) state was examined using a binary logistic regression model. The association with HRQoL was examined with a linear regression model. All multivariable analyses were adjusted for possible confounders. Results: 266 SLE patients were included, 227 from the comprehensive care model and 39 from the regular care model. The regular care model was associated with a lower probability of achieving remission (OR 0.381; CI: 95% 0.163–0.887) and LLDAS (OR 0.363; CI: 95% 0.157–0.835). Regular care was associated with a better HRQoL in two domains (pain and emotional health). We found no association between the care model and the other HRQoL domains. Conclusion: A comprehensive care model was associated with the probability of achieving remission and LLDAS but had no apparent impact on the patients’ HRQoL.

KW - Systemic lupus erythematosus

KW - care model

KW - damage

KW - health-related quality of care

KW - low lupus disease activity state

KW - remission

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DO - 10.1177/09612033211063798

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SN - 0961-2033

VL - 31

SP - 110

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JO - Lupus

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ER -

Relationship between care model and disease activity states and health-related quality of life in systemic lupus erythematosus patients

Abstract

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Keywords

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