Risk of cancer in family members of patients with lynch-like syndrome

María Dolores Picó; Ana Beatriz Sánchez-Heras; Adela Castillejo; Mar Giner-Calabuig; Miren Alustiza; Ariadna Sánchez; Leticia Moreira; María Pellise; Antoni Castells; Gemma Llort; Carmen Yagüe; Teresa Ramon Y. Cajal; Alexandra Gisbert-Beamud; Joaquin Cubiella; Laura Rivas; Maite Herraiz; Catalina Garau; Inmaculada Salces; Marta Carrillo-Palau; Luis Bujanda; Adriá López-Fernández; Cristina Alvarez-Urturi; María Jesús López; Cristina Alenda; Pedro Zapater; Francisco Javier Lacueva; Francesc Balaguer; Jose Luis Soto; Óscar Murcia; Rodrigo Jover

doi:10.3390/cancers12082225

Risk of cancer in family members of patients with lynch-like syndrome

María Dolores Picó, Ana Beatriz Sánchez-Heras, Adela Castillejo, Mar Giner-Calabuig, Miren Alustiza, Ariadna Sánchez, Leticia Moreira, María Pellise, Antoni Castells, Gemma Llort, Carmen Yagüe, Teresa Ramon Y. Cajal, Alexandra Gisbert-Beamud, Joaquin Cubiella, Laura Rivas, Maite Herraiz, Catalina Garau, Inmaculada Salces, Marta Carrillo-Palau, Luis BujandaAdriá López-Fernández, Cristina Alvarez-Urturi, María Jesús López, Cristina Alenda, Pedro Zapater, Francisco Javier Lacueva, Francesc Balaguer, Jose Luis Soto, Óscar Murcia, Rodrigo Jover

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Lynch syndrome (LS) is a common cause of hereditary colorectal cancer (CRC). Some CRC patients develop mismatch repair deficiency without germline pathogenic mutation, known as Lynch-like syndrome (LLS). We compared the risk of CRC in first-degree relatives (FDRs) in LLS and LS patients. LLS was diagnosed when tumors showed immunohistochemical loss of MSH2, MSH6, and PMS2; or loss of MLH1 with BRAF wild type; and/or no MLH1 methylation and absence of pathogenic mutation in these genes. CRC and other LS-related neoplasms were followed in patients diagnosed with LS and LLS and among their FDRs. Standardized incidence ratios (SIRs) were calculated for CRC and other neoplasms associated with LS among FDRs of LS and LLS patients. In total, 205 LS (1205 FDRs) and 131 LLS families (698 FDRs) had complete pedigrees. FDRs of patients with LLS had a high incidence of CRC (SIR, 2.08; 95% confidence interval (CI), 1.56–2.71), which was significantly lower than that in FDRs of patients with LS (SIR, 4.25; 95% CI, 3.67–4.90; p < 0.001). The risk of developing other neoplasms associated with LS also increased among FDR of LLS patients (SIR, 2.04; 95% CI, 1.44–2.80) but was lower than that among FDR of patients with LS (SIR, 5.01, 95% CI, 4.26–5.84; p < 0.001). FDRs with LLS have an increased risk of developing CRC as well as LS-related neoplasms, although this risk is lower than that of families with LS. Thus, their management should take into account this increased risk.

Original language	English
Article number	2225
Pages (from-to)	1-12
Number of pages	12
Journal	Cancers
Volume	12
Issue number	8
DOIs	https://doi.org/10.3390/cancers12082225
State	Published - Aug 2020

Bibliographical note

Funding Information:
Funding: This work was supported by the Instituto de Salud Carlos III (PI08/0726, INT-09/208, PI11/2630, INT-12-078, INT13-196, PI14/01386, PI17/01756), Fundación de Investigación Biomédica de la Comunidad Valenciana–Instituto de Investigación Sanitaria y Biomédica de Alicante Foundation (UGP-14-120, UGP-13-221, UGP-14-265), and the Asociación Española Contra el Cáncer (Fundación Científica GCB13131592CAST). Mar Giner-Calabuig received a pre-doctoral grant from Conselleria d’Educació de la Generalitat Valenciana (VALi+d. EXP ACIF/2010/018, ACIF/2016/002). Miren Alustiza received a pre-doctoral grant from Instituto de Investigación Sanitaria y Biomédica de Alicante ISABIAL. Oscar Murcia received a grant Rio-Hortega from Instituto de Salud Carlos III. Asociación para la Investigación en Gastroenterología de la Provincia de Alicante (AIGPA), a private association that promotes research in gastrointestinal diseases in Alicante, also supported the logistical aspects of the study. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results

Funding Information:
This work was supported by the Instituto de Salud Carlos III (PI08/0726, INT-09/208, PI11/2630, INT-12-078, INT13-196, PI14/01386, PI17/01756), Fundaci?n de Investigaci?n Biom?dica de la Comunidad Valenciana?Instituto de Investigaci?n Sanitaria y Biom?dica de Alicante Foundation (UGP-14-120, UGP-13-221, UGP-14-265), and the Asociaci?n Espa?ola Contra el C?ncer (Fundaci?n Cient?fica GCB13131592CAST). Mar Giner-Calabuig received a pre-doctoral grant from Conselleria d?Educaci? de la Generalitat Valenciana (VALi+d. EXP ACIF/2010/018, ACIF/2016/002). Miren Alustiza received a pre-doctoral grant from Instituto de Investigaci?n Sanitaria y Biom?dica de Alicante ISABIAL. Oscar Murcia received a grant Rio-Hortega from Instituto de Salud Carlos III. Asociaci?n para la Investigaci?n en Gastroenterolog?a de la Provincia de Alicante (AIGPA), a private association that promotes research in gastrointestinal diseases in Alicante, also supported the logistical aspects of the study. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Colorectal cancer
Genetic
Risk
Surveillance

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10.3390/cancers12082225

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Picó, M. D., Sánchez-Heras, A. B., Castillejo, A., Giner-Calabuig, M., Alustiza, M., Sánchez, A., Moreira, L., Pellise, M., Castells, A., Llort, G., Yagüe, C., Cajal, T. R. Y., Gisbert-Beamud, A., Cubiella, J., Rivas, L., Herraiz, M., Garau, C., Salces, I., Carrillo-Palau, M., ... Jover, R. (2020). Risk of cancer in family members of patients with lynch-like syndrome. Cancers, 12(8), 1-12. [2225]. https://doi.org/10.3390/cancers12082225

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title = "Risk of cancer in family members of patients with lynch-like syndrome",

abstract = "Lynch syndrome (LS) is a common cause of hereditary colorectal cancer (CRC). Some CRC patients develop mismatch repair deficiency without germline pathogenic mutation, known as Lynch-like syndrome (LLS). We compared the risk of CRC in first-degree relatives (FDRs) in LLS and LS patients. LLS was diagnosed when tumors showed immunohistochemical loss of MSH2, MSH6, and PMS2; or loss of MLH1 with BRAF wild type; and/or no MLH1 methylation and absence of pathogenic mutation in these genes. CRC and other LS-related neoplasms were followed in patients diagnosed with LS and LLS and among their FDRs. Standardized incidence ratios (SIRs) were calculated for CRC and other neoplasms associated with LS among FDRs of LS and LLS patients. In total, 205 LS (1205 FDRs) and 131 LLS families (698 FDRs) had complete pedigrees. FDRs of patients with LLS had a high incidence of CRC (SIR, 2.08; 95% confidence interval (CI), 1.56–2.71), which was significantly lower than that in FDRs of patients with LS (SIR, 4.25; 95% CI, 3.67–4.90; p < 0.001). The risk of developing other neoplasms associated with LS also increased among FDR of LLS patients (SIR, 2.04; 95% CI, 1.44–2.80) but was lower than that among FDR of patients with LS (SIR, 5.01, 95% CI, 4.26–5.84; p < 0.001). FDRs with LLS have an increased risk of developing CRC as well as LS-related neoplasms, although this risk is lower than that of families with LS. Thus, their management should take into account this increased risk.",

keywords = "Colorectal cancer, Genetic, Risk, Surveillance",

author = "Pic{\'o}, {Mar{\'i}a Dolores} and S{\'a}nchez-Heras, {Ana Beatriz} and Adela Castillejo and Mar Giner-Calabuig and Miren Alustiza and Ariadna S{\'a}nchez and Leticia Moreira and Mar{\'i}a Pellise and Antoni Castells and Gemma Llort and Carmen Yag{\"u}e and Cajal, {Teresa Ramon Y.} and Alexandra Gisbert-Beamud and Joaquin Cubiella and Laura Rivas and Maite Herraiz and Catalina Garau and Inmaculada Salces and Marta Carrillo-Palau and Luis Bujanda and Adri{\'a} L{\'o}pez-Fern{\'a}ndez and Cristina Alvarez-Urturi and L{\'o}pez, {Mar{\'i}a Jes{\'u}s} and Cristina Alenda and Pedro Zapater and Lacueva, {Francisco Javier} and Francesc Balaguer and Soto, {Jose Luis} and {\'O}scar Murcia and Rodrigo Jover",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = aug,

doi = "10.3390/cancers12082225",

language = "Ingl{\'e}s",

volume = "12",

pages = "1--12",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute",

number = "8",

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Picó, MD, Sánchez-Heras, AB, Castillejo, A, Giner-Calabuig, M, Alustiza, M, Sánchez, A, Moreira, L, Pellise, M, Castells, A, Llort, G, Yagüe, C, Cajal, TRY, Gisbert-Beamud, A, Cubiella, J, Rivas, L, Herraiz, M, Garau, C, Salces, I, Carrillo-Palau, M, Bujanda, L, López-Fernández, A, Alvarez-Urturi, C, López, MJ, Alenda, C, Zapater, P, Lacueva, FJ, Balaguer, F, Soto, JL, Murcia, Ó & Jover, R 2020, 'Risk of cancer in family members of patients with lynch-like syndrome', Cancers, vol. 12, no. 8, 2225, pp. 1-12. https://doi.org/10.3390/cancers12082225

TY - JOUR

T1 - Risk of cancer in family members of patients with lynch-like syndrome

AU - Picó, María Dolores

AU - Sánchez-Heras, Ana Beatriz

AU - Castillejo, Adela

AU - Giner-Calabuig, Mar

AU - Alustiza, Miren

AU - Sánchez, Ariadna

AU - Moreira, Leticia

AU - Pellise, María

AU - Castells, Antoni

AU - Llort, Gemma

AU - Yagüe, Carmen

AU - Cajal, Teresa Ramon Y.

AU - Gisbert-Beamud, Alexandra

AU - Cubiella, Joaquin

AU - Rivas, Laura

AU - Herraiz, Maite

AU - Garau, Catalina

AU - Salces, Inmaculada

AU - Carrillo-Palau, Marta

AU - Bujanda, Luis

AU - López-Fernández, Adriá

AU - Alvarez-Urturi, Cristina

AU - López, María Jesús

AU - Alenda, Cristina

AU - Zapater, Pedro

AU - Lacueva, Francisco Javier

AU - Balaguer, Francesc

AU - Soto, Jose Luis

AU - Murcia, Óscar

AU - Jover, Rodrigo

PY - 2020/8

Y1 - 2020/8

N2 - Lynch syndrome (LS) is a common cause of hereditary colorectal cancer (CRC). Some CRC patients develop mismatch repair deficiency without germline pathogenic mutation, known as Lynch-like syndrome (LLS). We compared the risk of CRC in first-degree relatives (FDRs) in LLS and LS patients. LLS was diagnosed when tumors showed immunohistochemical loss of MSH2, MSH6, and PMS2; or loss of MLH1 with BRAF wild type; and/or no MLH1 methylation and absence of pathogenic mutation in these genes. CRC and other LS-related neoplasms were followed in patients diagnosed with LS and LLS and among their FDRs. Standardized incidence ratios (SIRs) were calculated for CRC and other neoplasms associated with LS among FDRs of LS and LLS patients. In total, 205 LS (1205 FDRs) and 131 LLS families (698 FDRs) had complete pedigrees. FDRs of patients with LLS had a high incidence of CRC (SIR, 2.08; 95% confidence interval (CI), 1.56–2.71), which was significantly lower than that in FDRs of patients with LS (SIR, 4.25; 95% CI, 3.67–4.90; p < 0.001). The risk of developing other neoplasms associated with LS also increased among FDR of LLS patients (SIR, 2.04; 95% CI, 1.44–2.80) but was lower than that among FDR of patients with LS (SIR, 5.01, 95% CI, 4.26–5.84; p < 0.001). FDRs with LLS have an increased risk of developing CRC as well as LS-related neoplasms, although this risk is lower than that of families with LS. Thus, their management should take into account this increased risk.

AB - Lynch syndrome (LS) is a common cause of hereditary colorectal cancer (CRC). Some CRC patients develop mismatch repair deficiency without germline pathogenic mutation, known as Lynch-like syndrome (LLS). We compared the risk of CRC in first-degree relatives (FDRs) in LLS and LS patients. LLS was diagnosed when tumors showed immunohistochemical loss of MSH2, MSH6, and PMS2; or loss of MLH1 with BRAF wild type; and/or no MLH1 methylation and absence of pathogenic mutation in these genes. CRC and other LS-related neoplasms were followed in patients diagnosed with LS and LLS and among their FDRs. Standardized incidence ratios (SIRs) were calculated for CRC and other neoplasms associated with LS among FDRs of LS and LLS patients. In total, 205 LS (1205 FDRs) and 131 LLS families (698 FDRs) had complete pedigrees. FDRs of patients with LLS had a high incidence of CRC (SIR, 2.08; 95% confidence interval (CI), 1.56–2.71), which was significantly lower than that in FDRs of patients with LS (SIR, 4.25; 95% CI, 3.67–4.90; p < 0.001). The risk of developing other neoplasms associated with LS also increased among FDR of LLS patients (SIR, 2.04; 95% CI, 1.44–2.80) but was lower than that among FDR of patients with LS (SIR, 5.01, 95% CI, 4.26–5.84; p < 0.001). FDRs with LLS have an increased risk of developing CRC as well as LS-related neoplasms, although this risk is lower than that of families with LS. Thus, their management should take into account this increased risk.

KW - Colorectal cancer

KW - Genetic

KW - Risk

KW - Surveillance

UR - http://www.scopus.com/inward/record.url?scp=85090368369&partnerID=8YFLogxK

U2 - 10.3390/cancers12082225

DO - 10.3390/cancers12082225

M3 - Artículo

AN - SCOPUS:85090368369

SN - 2072-6694

VL - 12

SP - 1

EP - 12

JO - Cancers

JF - Cancers

IS - 8

M1 - 2225

ER -

Risk of cancer in family members of patients with lynch-like syndrome

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Keywords

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