Scavenger mechanism of methylglyoxal by metformin. A DFT study

Christian Solís-Calero; Joaquín Ortega-Castro; Juan Frau; Francisco Muñoz

doi:10.1007/s00214-015-1649-z

Scavenger mechanism of methylglyoxal by metformin. A DFT study

Christian Solís-Calero, Joaquín Ortega-Castro, Juan Frau, Francisco Muñoz

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10 Scopus citations

Abstract

We have studied the mechanism of the reaction between the most stable and the most represented in literature tautomers of metformin and methylglyoxal by density functional theory calculations. Designed models included 16 explicit water solvent, which forms hydrogen bond networks around the reactants and intermediates molecules, facilitating intramolecular proton transfer in some steps of the reaction mechanism. The reaction takes place in five steps, namely: (1) formation of a dimethylguanide–guanylhydrazone–acetylcarbinol adduct, (2) formation of a zwitterionic triazepine derivative by ring closure, (3) dehydration of this intermediate, (4) an imine–enamine tautomerism, (5) an enol–keto tautomerism. The first step was found as the rate-determining step for the reaction, having the reaction an overall activation energy value of 9.7 kcal mol⁻¹.

Original language	English
Article number	48
Journal	Theoretical Chemistry Accounts
Volume	134
Issue number	4
DOIs	https://doi.org/10.1007/s00214-015-1649-z
State	Published - 1 Apr 2015

Bibliographical note

Funding Information:
The financial support of Govern de les Illes Balears (AAEE27/2014) is gratefully acknowledged. C.S.-C. is grateful to the Spanish Ministry of Foreign Affairs and Cooperation for the award of a MAE-AECI fellowship. We are grateful to Centro de cálculo de Computación de Galicia (CESGA) and the Centro de cálculo de Computación de Cataluña (CESCA) for allowing the use of their computational facilities.

Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.

Keywords

AGEs
DFT calculations
Metformin
Methylglyoxal
Non-enzymatic glycation
Triazepine derivatives
α-Dicarbonyl compound

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abstract = "We have studied the mechanism of the reaction between the most stable and the most represented in literature tautomers of metformin and methylglyoxal by density functional theory calculations. Designed models included 16 explicit water solvent, which forms hydrogen bond networks around the reactants and intermediates molecules, facilitating intramolecular proton transfer in some steps of the reaction mechanism. The reaction takes place in five steps, namely: (1) formation of a dimethylguanide–guanylhydrazone–acetylcarbinol adduct, (2) formation of a zwitterionic triazepine derivative by ring closure, (3) dehydration of this intermediate, (4) an imine–enamine tautomerism, (5) an enol–keto tautomerism. The first step was found as the rate-determining step for the reaction, having the reaction an overall activation energy value of 9.7 kcal mol−1.",

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AU - Solís-Calero, Christian

AU - Ortega-Castro, Joaquín

AU - Frau, Juan

AU - Muñoz, Francisco

PY - 2015/4/1

Y1 - 2015/4/1

N2 - We have studied the mechanism of the reaction between the most stable and the most represented in literature tautomers of metformin and methylglyoxal by density functional theory calculations. Designed models included 16 explicit water solvent, which forms hydrogen bond networks around the reactants and intermediates molecules, facilitating intramolecular proton transfer in some steps of the reaction mechanism. The reaction takes place in five steps, namely: (1) formation of a dimethylguanide–guanylhydrazone–acetylcarbinol adduct, (2) formation of a zwitterionic triazepine derivative by ring closure, (3) dehydration of this intermediate, (4) an imine–enamine tautomerism, (5) an enol–keto tautomerism. The first step was found as the rate-determining step for the reaction, having the reaction an overall activation energy value of 9.7 kcal mol−1.

AB - We have studied the mechanism of the reaction between the most stable and the most represented in literature tautomers of metformin and methylglyoxal by density functional theory calculations. Designed models included 16 explicit water solvent, which forms hydrogen bond networks around the reactants and intermediates molecules, facilitating intramolecular proton transfer in some steps of the reaction mechanism. The reaction takes place in five steps, namely: (1) formation of a dimethylguanide–guanylhydrazone–acetylcarbinol adduct, (2) formation of a zwitterionic triazepine derivative by ring closure, (3) dehydration of this intermediate, (4) an imine–enamine tautomerism, (5) an enol–keto tautomerism. The first step was found as the rate-determining step for the reaction, having the reaction an overall activation energy value of 9.7 kcal mol−1.

KW - AGEs

KW - DFT calculations

KW - Metformin

KW - Methylglyoxal

KW - Non-enzymatic glycation

KW - Triazepine derivatives

KW - α-Dicarbonyl compound

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DO - 10.1007/s00214-015-1649-z

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SN - 1432-881X

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JO - Theoretical Chemistry Accounts

JF - Theoretical Chemistry Accounts

IS - 4

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ER -

Scavenger mechanism of methylglyoxal by metformin. A DFT study

Abstract

Bibliographical note

Keywords

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