Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential

Jan Tauchen, Lukas Huml, Ludvik Bortl, Ivo Doskocil, Veronika Jarosova, Petr Marsik, Adela Frankova, Zoyla Mirella Clavo Peralta, Maria Elena Chuspe Zans, Jaroslav Havlik, Oldrich Lapcik, Ladislav Kokoska

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80.6 and 687.3 μg TE/mg extract, respectively; IC50 against Caco-2, HT-29 and Hep-G2 = 129.2, 69.9 and 130.6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or anti-proliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/anti-proliferative activity of this plant should be carried out in order to verify its potential practical use.
Original languageAmerican English
Pages (from-to)2718-2721
Number of pages4
JournalNatural Product Research
DOIs
StatePublished - 17 Sep 2019

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