TY - JOUR
T1 - Serodiagnosis of Bartonella bacilliformis infection by indirect fluorescence antibody assay
T2 - Test development and application to a population in an area of bartonellosis endemicity
AU - Chamberlin, J.
AU - Laughlin, L.
AU - Gordon, S.
AU - Romero, S.
AU - Solórzano, N.
AU - Regnery, R. L.
PY - 2000
Y1 - 2000
N2 - Bartonella bacilliformis causes bartonellosis, a potentially life-threatening emerging infectious disease seen in the Andes Mountains of South America. There are no generally accepted serologic tests to confirm the disease. We developed an indirect fluorescence antibody (IFA) test for the detection of antibodies to B. bacilliformis and then tested its performance as an aid in the diagnosis of acute bartonellosis. The IFA is 82% sensitive in detecting B. bacilliformis antibodies in acute-phase blood samples of laboratory-confirmed bartonellosis patients. When used to examine convalescent-phase sera, the IFA is positive in 93% of bartonellosis cases. The positive predictive value of the test is 89% in an area of Peru where B. bacilliformis is endemic and where the point prevalence of infection is 45%.
AB - Bartonella bacilliformis causes bartonellosis, a potentially life-threatening emerging infectious disease seen in the Andes Mountains of South America. There are no generally accepted serologic tests to confirm the disease. We developed an indirect fluorescence antibody (IFA) test for the detection of antibodies to B. bacilliformis and then tested its performance as an aid in the diagnosis of acute bartonellosis. The IFA is 82% sensitive in detecting B. bacilliformis antibodies in acute-phase blood samples of laboratory-confirmed bartonellosis patients. When used to examine convalescent-phase sera, the IFA is positive in 93% of bartonellosis cases. The positive predictive value of the test is 89% in an area of Peru where B. bacilliformis is endemic and where the point prevalence of infection is 45%.
UR - http://www.scopus.com/inward/record.url?scp=0034460181&partnerID=8YFLogxK
U2 - 10.1128/jcm.38.11.4269-4271.2000
DO - 10.1128/jcm.38.11.4269-4271.2000
M3 - Artículo
C2 - 11060108
AN - SCOPUS:0034460181
SN - 0095-1137
VL - 38
SP - 4269
EP - 4271
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 11
ER -