We performed repeated serological sampling of pigs in an endemic area of the Peruvian highlands (eight villages) to assess the feasibility of detecting incident cases of Taenia solium infection as indicators of ongoing transmission of the parasite. A total of 2245 samples corresponding to 1548 pigs were collected in three sampling rounds (n = 716, 926, and 603, respectively). Village-period specific seroprevalences of antibodies by enzyme-linked immunoelectrotransfer blot (EITB) assay varied from 39% (95% CI: 34, 44) to 76% (95% CI: 72, 79). The prevalence of cysticercosis increased with the age of the pigs (similarly for both sexes). Around 40% of pigs were re-sampled at the end of each 4-month period. Crude incidence risks were 48% (57/120, 95% CI: 43-52) and 58% (111/192, 95% CI: 54-61) for each period. A proportion of seropositive animals became seronegative at the end of each period (23 and 15%). Incidence varied by the village, and the exposure period, and was higher in males than females (but did not differ by age).
Bibliographical noteFunding Information:
We are indebted to the people of the Mantaro Valley, who allowed us to do this study. Help from Dr. L.H. Moulton and from M.T. Lopez, C. Guezala, P. Rodriguez, E. Perez, A. Ramirez and C. Taquiri in sample management and data collection is acknowledged. This study was mainly funded by grant number U19 A145431 from National Institutes for Health, ABC, and ITREID from NIH/Fogarty Foundation, USA.
- Longitudinal studies
- Taenia solium