Serum monitoring of carbamazepine in patients with epilepsy and clinical implications

Angel T. Alvarado, Gustavo Paredes, Gregoriana García, Alexis Morales, Ana María Muñoz, María Saravia, Ricardo Losno, María R. Bendezú, Haydee Chávez, Jorge A. García, Mario Pineda, Luis Sullón-Dextre

Research output: Contribution to journalArticlepeer-review

Abstract

Carbamazepine is a drug with a narrow therapeutic range that requires clinical monitoring, since its toxic effects are not easily predictable, and the therapeutic level can vary. Our study aimed to monitor the serum level and determine the concentration/dose relationship of carbamazepine in people with epilepsy, analyzing its clinical implication. It is observed that 90.48% of the study volunteers present serum level values (4.3–10.4 mg/L) within the therapeutic range (4–12 mg/L); 7.14% present supratherapeutic levels (12.7–14.4 mg/L), 2.38% subtherapeutic (0.93 mg/L). The findings indicate a negative correlation (r = -0.616; r2 = 0.379; p = 0.001), between the dose (mg/day) and the dose ratio (mg/L/mg/day); and a positive correlation (r = 0.544; r2 = 0.296; p = 0.002), between the dose (mg/day)-serum concentration (mg/L). ANOVA and Tukey’s test mean difference is significant (p<0.05). It is concluded that there is a positive and significant linear correlation between daily doses and serum carbamazepine concentrations, which should be considered to individualize the dose and optimize clinical results.

Original languageEnglish
Pages (from-to)401-406
Number of pages6
JournalPharmacia
Volume69
Issue number2
DOIs
StatePublished - 2022
Externally publishedYes

Bibliographical note

Funding Information:
Society of Molecular Pharmacology of Peru, and Latin American Society of Pharmacogenomics and Personalized Medicine.

Publisher Copyright:
© Alvarado AT et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Keywords

  • Carbamazepine
  • Level/dose
  • Personalized dose
  • Serum monitoring
  • Therapeutic range

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