Serum uric acid is associated with damage in patients with systemic lupus erythematosus

Claudia Elera-Fitzcarrald, Cristina Reátegui-Sokolova, Rocio Violeta Gamboa-Cardenas, Mariela Medina, Francisco Zevallos, Victor Román Pimentel-Quiroz, Jorge Mariano Cucho-Venegas, José Alfaro-Lozano, Zoila Rodriguez-Bellido, Cesar Augusto Pastor-Asurza, Risto Alfredo Perich-Campos, Graciela S. Alarcón, Manuel Francisco Ugarte-Gil

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Introduction Serum uric acid levels have been reported as predictors of cardiovascular, pulmonary, neurological and renal morbidity in patients with SLE. However, their role in cumulative global damage in these patients has not yet been determined. Objective To determine whether serum uric acid levels are associated with new damage in patients with SLE. Methods This is a longitudinal study of patients with SLE from the Almenara Lupus Cohort, which began in 2012. At each visit, demographic and clinical characteristics were evaluated, such as activity (Systemic Lupus Erythematosus Disease Activity Index-2K or SLEDAI-2K) and cumulative damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index or SDI). Treatment (glucocorticoids, immunosuppressive drugs and antimalarials) was also recorded. Univariable and multivariable Cox regression models were used to determine the impact of serum uric acid levels on the risk of new damage. Results We evaluated 237 patients, with a mean age (SD) at diagnosis of 35.9 (13.1) years; 220 patients (92.8%) were women, and the duration of the disease was 7.3 (6.6) years. The mean SLEDAI-2K and SDI scores were 5.1 (4.2) and 0.9 (1.3), respectively. Serum uric acid level was 4.5 (1.4) mg/dL. Follow-up time was 3.1 (1.3) years, and 112 (47.3%) patients accrued damage during follow-up. In univariable and multivariable analyses, serum uric acid levels were associated with new damage (HR=1.141 (95% CI 1.016 to 1.282), p=0.026; HR=1.189 (95% CI 1.025 to 1.378), p=0.022, respectively). Conclusion Higher serum uric acid levels are associated with global damage in patients with SLE.

Original languageEnglish
Article numbere000366
JournalLupus Science and Medicine
Volume7
Issue number1
DOIs
StatePublished - 5 Feb 2020

Bibliographical note

Funding Information:
Funding This work was partially supported by an institutional grant from EsSalud (1483-GCGP-ESSALUD-2013, 1733-GCGP-ESSALUD-2014 and 04-IETSI-ESALUD-2016 2015, Kaelin Prize) and one from the Panamerican League of Associations for Rheumatology (PANLAR) (2015 PANLAR Prize).

Publisher Copyright:
© © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • autoimmune diseases
  • autoimmunity
  • systemic lupus erythematosus

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