Short report: Transient antibody response in Taenia solium infection in field conditions - A major contributor to high seroprevalence

H. H. Garcia, Armando Emiliano Gonzalez Zariquiey, R. H. Gilman, L. G. Palacios, I. Jimenez, S. Rodriguez, M. Verastegui, P. Wilkins, V. C.W. Tsang, P. Torres, J. Pretell, Cesar Miguel Gavidia Chucan, N. Falcon, T. Bernal, M. Martinez, J. Noh

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

The discordance between extremely high seroprevalence of Taenia solium antibodies in disease-endemic populations, relatively few symptomatic cases of neurocysticercosis, and high background levels of putatively inactive brain lesions (mainly calcifications) in seronegative controls have confused researchers, clinicians, and epidemiologists in the last decade. We reviewed longitudinal serologic data from general population serosurveys in 3 different disease-endemic areas of Peru and Colombia and found that ∼40% of seropositive people were seronegative when resampled after 1 year (3 surveys) or after 3 years (1 survey). Transient antibodies may have significant implications for the epidemiology of and immunity to this disease.

Original languageEnglish
Pages (from-to)31-32
Number of pages2
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume65
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

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