TY - JOUR
T1 - Successful immunization of naturally reared pigs against porcine cysticercosis with a recombinant oncosphere antigen vaccine
AU - Jayashi, César M.
AU - Kyngdon, Craig T.
AU - Gauci, Charles G.
AU - Gonzalez, Armando E.
AU - Lightowlers, Marshall W.
PY - 2012/9/10
Y1 - 2012/9/10
N2 - Taenia solium causes cysticercosis in pigs and taeniasis and neurocysticercosis in humans. Oncosphere antigens have proven to be effective as vaccines to protect pigs against an experimental infection with T. solium. A pair-matched vaccination trial field, using a combination of two recombinant antigens, TSOL16 and TSOL18, was undertaken in rural villages of Peru to evaluate the efficacy of this vaccine under natural conditions. Pairs of pigs (n=137) comprising one vaccinated and one control animal, were allocated to local villagers. Animals received two vaccinations with 200. μg of each of TSOL16 and TSOL18, plus 5. mg Quil-A. Necropsies were performed 7 months after the animals were distributed to the farmers. Vaccination reduced 99.7% and 99.9% (p<0.01) the total number of cysts and the number of viable cysts, respectively. Immunization with the TSOL16-TSOL18 vaccines has the potential to control T. solium transmission in areas where the disease is endemic, reducing the source for tapeworm infections in humans. © 2012 Elsevier B.V.
AB - Taenia solium causes cysticercosis in pigs and taeniasis and neurocysticercosis in humans. Oncosphere antigens have proven to be effective as vaccines to protect pigs against an experimental infection with T. solium. A pair-matched vaccination trial field, using a combination of two recombinant antigens, TSOL16 and TSOL18, was undertaken in rural villages of Peru to evaluate the efficacy of this vaccine under natural conditions. Pairs of pigs (n=137) comprising one vaccinated and one control animal, were allocated to local villagers. Animals received two vaccinations with 200. μg of each of TSOL16 and TSOL18, plus 5. mg Quil-A. Necropsies were performed 7 months after the animals were distributed to the farmers. Vaccination reduced 99.7% and 99.9% (p<0.01) the total number of cysts and the number of viable cysts, respectively. Immunization with the TSOL16-TSOL18 vaccines has the potential to control T. solium transmission in areas where the disease is endemic, reducing the source for tapeworm infections in humans. © 2012 Elsevier B.V.
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U2 - 10.1016/j.vetpar.2012.03.055
DO - 10.1016/j.vetpar.2012.03.055
M3 - Article
SN - 0304-4017
SP - 261
EP - 267
JO - Veterinary Parasitology
JF - Veterinary Parasitology
ER -
