Synthesis and evaluation of arylquinones as BACE1 inhibitors, β-amyloid peptide aggregation inhibitors, and destabilizers of preformed β-amyloid fibrils

Medicine & Life Sciences

• Amyloid 100%
• Psychological Inhibition 86%
• Peptides 67%
• Alzheimer Disease 54%
• Quinones 50%
• Human immunodeficiency virus 1 reverse transcriptase 48%
• Amyloid beta-Protein Precursor 40%
• Biological Products 34%
• Hypoglycemic Agents 33%
• Drug Development 33%
• Anti-Bacterial Agents 23%
• Pharmaceutical Preparations 14%

Chemical Compounds

• Peptide 60%
• Drug 55%
• Quinone 50%
• Antitumor 48%
• Occurrence in Nature 43%
• Bioactivity 37%
• Antimicrobial Agent 36%
• Protein 21%