Synthesis, crystal structure, catalytic and anti-Trypanosoma cruzi activity of a new chromium(III) complex containing bis(3,5-dimethylpyrazol-1-yl)methane

John Hurtado, Laura Ibarra, David Yepes, Paola García-Huertas, Mario A. Macías, Omar Triana-Chavez, Edgar Nagles, Leopoldo Suescun, Alvaro Muñoz-Castro

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10 Scopus citations

Abstract

The reaction of CrCl36H2O with the ligand bis(3,5-dimethylpyrazol-1-yl)methane (L) yielded the cationic complex [(Cr(L)(H2O)2Cl2]+, which crystallized as the chloride trihydrate [(Cr(L)(H2O)2Cl2]Cl·3H2O. The chromium complex was characterized by elemental analysis, electrical conductivity, Infrared and Ultraviolet/Visible spectroscopy. The crystal structure determination using single-crystal X-ray diffraction showed a chromium center in a distorted octahedral coordination sphere. In the crystal, the packing was directed by O[sbnd]H⋯(O,Cl) hydrogen bonds and weak C[sbnd]H⋯O interactions to build a monoclinic P21/c supramolecular structure. The complex showed excellent properties as an initiator for the ring opening polymerization of є-caprolactone (CL) under solvent-free conditions. The obtained polymer showed high crystallinity (89.9%) and a decomposition temperature above 475 °C. In addition, the new complex was evaluated against epimastigotes from Trypanosoma cruzi (T. cruzi) strains. The results indicated that this complex has a high activity against this parasite with a minimum inhibitory concentration 50 (MIC50) of 1.08 μg/mL. Interestingly, this compound showed little effect on erythrocytes, indicating that it is not cytotoxic. These results provide interesting contributions to the design of metal complexes by using simple and accessible ligands with activity against T. cruzi and with potential applications in the polymerization of CL.

Original languageEnglish
Pages (from-to)365-372
Number of pages8
JournalJournal of Molecular Structure
Volume1146
DOIs
StatePublished - 15 Oct 2017

Bibliographical note

Funding Information:
Thanks to the Department of Chemistry and the School of Science of the Universidad de los Andes for the financial support. O. Triana acknowledges the Universidad de Antioquia-UdeA. E. Nagles acknowledges the Ibague University project 16-416-INT. M. Mac?as wishes to thank ANII (EQC_2012_07), CSIC and Facultad de Qu?mica for the funds to purchase the diffractometer. MAM also thanks ANII for his post-doctoral contract (PD_NAC_2014_1_102409). A. Mu?oz-Castro thanks FONDECYT 1140359 for financial support. We thank the reviewers and editor for their useful comments.

Publisher Copyright:
© 2017 Elsevier B.V.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • Chromium complex
  • Crystal structure
  • Ring opening polymerization
  • Trypanosoma cruzi
  • ε-caprolactone

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