Synthesis of nanoparticles of the chitosan-poly((α,β)-DL-aspartic acid) polyelectrolite complex as hydrophilic drug carrier

Carmen L. Zegarra-Urquia, Julio Santiago, Joel D. Bumgardner, José Vega-Baudrit, Claudia A. Hernández-Escobar, E. Armando Zaragoza-Contreras

Research output: Contribution to journalArticlepeer-review

Abstract

In this work, nanoparticles of the chitosan-poly((α,β)-DL-aspartic acid) polyelectrolyte complex (PEC) were synthesized. The purpose is to develop a biodegradable, biocompatible, and non-toxic polymeric platform as a vehicle for the encapsulation of hydrophilic drugs. The ionotropic gelation method, using solutions of chitosan and poly((α,β)-DL-aspartic acid sodium salt), allowed synthesizing particles with diameters of 142.1 ± 2.9 nm determined by DLS, while by FESEM particle diameters in the 60–200 nm range were observed. A preliminary trial showed that encapsulation of isoniazid, a hydrophilic drug to treat tuberculosis, is possible with encapsulation efficiency in the range of 5.3–5.8%.

Original languageEnglish
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
DOIs
StateAccepted/In press - 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.

Keywords

  • Encapsulation
  • ionotropic gelation
  • nanoparticles
  • poly(aspartic acid)
  • polyelectrolyte complexes
  • polysuccinimide

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