Tetradentate metal complexes derived from cephalexin and 2,6-diacetylpyridine bis(hydrazone): Synthesis, characterization and antibacterial activity

J. R. Anacona, Victor Rangel, Marcos Antonio Loroño Gonzalez, Juan Camus

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Abstract Metal(II) coordination compounds of a hydrazone ligand (HL) derived from the condensation of cephalexin antibiotic with 2,6-diacetylpyridine bis(hydrazone) were synthesized. The hydrazone ligand and mononuclear [ML(H2O)2][PF6] (M(II) = Mn, Co, Ni, Zn) complexes were characterized by several techniques, including elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR, EPR and 1H NMR spectral studies. The cephalexin 2,6-diacetylpyridine bis(hydrazone) ligand HL behaves as a monoanionic tetradentate NNNO chelating agent. The biological applications of complexes have been studied on two bacteria strains (Escherichia coli and Staphylococcus aureus) by agar diffusion disc method.

Original languageEnglish
Article number13605
Pages (from-to)23-29
Number of pages7
JournalSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume149
DOIs
StatePublished - 5 Oct 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • Antibacterial activity
  • Cephalexin 2,6-diacetylpyridine bis(hydrazone) ligand
  • Hydrazone metal complexes
  • Synthesis hydrazone containing cephalexin

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