The Current Genomic Landscape of Western South America: Andes, Amazonia, and Pacific Coast

Chiara Barbieri, Rodrigo Barquera, Leonardo Arias, José R. Sandoval, Oscar Acosta, Camilo Zurita, Abraham Aguilar-Campos, Ana M. Tito-Álvarez, Ricardo Serrano-Osuna, Russell D. Gray, Fabrizio Mafessoni, Paul Heggarty, Kentaro K. Shimizu, Ricardo Fujita, Mark Stoneking, Irina Pugach, Lars Fehren-Schmitz

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Studies of Native South American genetic diversity have helped to shed light on the peopling and differentiation of the continent, but available data are sparse for the major ecogeographic domains. These include the Pacific Coast, a potential early migration route; the Andes, home to the most expansive complex societies and to one of the most widely spoken indigenous language families of the continent (Quechua); and Amazonia, with its understudied population structure and rich cultural diversity. Here, we explore the genetic structure of 176 individuals from these three domains, genotyped with the Affymetrix Human Origins array. We infer multiple sources of ancestry within the Native American ancestry component; one with clear predominance on the Coast and in the Andes, and at least two distinct substrates in neighboring Amazonia, including a previously undetected ancestry characteristic of northern Ecuador and Colombia. Amazonian populations are also involved in recent gene-flow with each other and across ecogeographic domains, which does not accord with the traditional view of small, isolated groups. Long-distance genetic connections between speakers of the same language family suggest that indigenous languages here were spread not by cultural contact alone. Finally, Native American populations admixed with post-Columbian European and African sources at different times, with few cases of prolonged isolation. With our results we emphasize the importance of including understudied regions of the continent in high-resolution genetic studies, and we illustrate the potential of SNP chip arrays for informative regional-scale analysis.

Original languageEnglish
Pages (from-to)2698-2713
Number of pages16
JournalMolecular Biology and Evolution
Volume36
Issue number12
DOIs
StatePublished - 1 Dec 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

Keywords

  • Native American population genetics
  • South American prehistory
  • admixture
  • human migration
  • runs of homozygosity

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