The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: A case-control study

Adela Castillejo; Trinidad Mata-Balaguer; Carla Guarinos; María Isabel Castillejo; Ana Martínez-Cantó; Víctor Manuel Barberá; Paola Montenegro; Enrique Ochoa; Rafael Lázaro; Carmen Guillén-Ponce; Alfredo Carrato; José Luís Soto

doi:10.1186/1471-2407-9-406

The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: A case-control study

Adela Castillejo, Trinidad Mata-Balaguer, Carla Guarinos, María Isabel Castillejo, Ana Martínez-Cantó, Víctor Manuel Barberá, Paola Montenegro, Enrique Ochoa, Rafael Lázaro, Carmen Guillén-Ponce, Alfredo Carrato, José Luís Soto

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background: The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1) has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC) has not been established. The aims of this study were to assess the association of TGFBR1*Int7G24A variant with CRC occurrence, patient age, gender, tumour location and stage. Methods: We performed a case-control study with 504 cases of sporadic CRC; and 504 non-cancerous age, gender and ethnically matched controls. Genotyping analysis was performed using allelic discrimination assay by real time PCR. Results: The Int7G24A variant was associated with increased CRC incidence in an additive model of inheritance (P for trend = 0.005). No significant differences were found between Int7G24A genotypes and tumour location or stage. Interestingly, the association of the Int7G24A variant with CRC risk was significant in men (odds ratio 4.10 with 95% confidence intervals 1.41-11.85 for homozygous individuals; P for trend = 0.00023), but not in women. We also observed an increase in susceptibility to CRC for individuals aged less than 70 years. Conclusion: Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population.

Original language	English
Article number	406
Journal	BMC Cancer
Volume	9
DOIs	https://doi.org/10.1186/1471-2407-9-406
State	Published - 20 Nov 2009

Bibliographical note

Funding Information:
This action has been performed within the cooperation framework established by the Transversal Cancer Action approved by the Council of Ministers on October 11th 2007 in accordance with the agreement between The Carlos III Health Institute (ISCIII), which is an autonomous entity currently belonging to the Ministry of Science and Innovation, and the Biomedical Research Foundation from the Hospital of Elche. Research supported in part by grants from the Generalitat Valenciana in Spain (AP106/06) and the Biomedical Research Foundation from the Hospital of Elche, Spain (FIBElx-02/2007). T.M-B is recipient of a fellowship from the Spanish Society of Medical Oncology (SEOM).

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Castillejo, A., Mata-Balaguer, T., Guarinos, C., Castillejo, M. I., Martínez-Cantó, A., Barberá, V. M., Montenegro, P., Ochoa, E., Lázaro, R., Guillén-Ponce, C., Carrato, A., & Soto, J. L. (2009). The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: A case-control study. BMC Cancer, 9, [406]. https://doi.org/10.1186/1471-2407-9-406

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title = "The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: A case-control study",

abstract = "Background: The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1) has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC) has not been established. The aims of this study were to assess the association of TGFBR1*Int7G24A variant with CRC occurrence, patient age, gender, tumour location and stage. Methods: We performed a case-control study with 504 cases of sporadic CRC; and 504 non-cancerous age, gender and ethnically matched controls. Genotyping analysis was performed using allelic discrimination assay by real time PCR. Results: The Int7G24A variant was associated with increased CRC incidence in an additive model of inheritance (P for trend = 0.005). No significant differences were found between Int7G24A genotypes and tumour location or stage. Interestingly, the association of the Int7G24A variant with CRC risk was significant in men (odds ratio 4.10 with 95% confidence intervals 1.41-11.85 for homozygous individuals; P for trend = 0.00023), but not in women. We also observed an increase in susceptibility to CRC for individuals aged less than 70 years. Conclusion: Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population.",

author = "Adela Castillejo and Trinidad Mata-Balaguer and Carla Guarinos and Castillejo, {Mar{\'i}a Isabel} and Ana Mart{\'i}nez-Cant{\'o} and Barber{\'a}, {V{\'i}ctor Manuel} and Paola Montenegro and Enrique Ochoa and Rafael L{\'a}zaro and Carmen Guill{\'e}n-Ponce and Alfredo Carrato and Soto, {Jos{\'e} Lu{\'i}s}",

note = "Funding Information: This action has been performed within the cooperation framework established by the Transversal Cancer Action approved by the Council of Ministers on October 11th 2007 in accordance with the agreement between The Carlos III Health Institute (ISCIII), which is an autonomous entity currently belonging to the Ministry of Science and Innovation, and the Biomedical Research Foundation from the Hospital of Elche. Research supported in part by grants from the Generalitat Valenciana in Spain (AP106/06) and the Biomedical Research Foundation from the Hospital of Elche, Spain (FIBElx-02/2007). T.M-B is recipient of a fellowship from the Spanish Society of Medical Oncology (SEOM).",

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doi = "10.1186/1471-2407-9-406",

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Castillejo, A, Mata-Balaguer, T, Guarinos, C, Castillejo, MI, Martínez-Cantó, A, Barberá, VM, Montenegro, P, Ochoa, E, Lázaro, R, Guillén-Ponce, C, Carrato, A & Soto, JL 2009, 'The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: A case-control study', BMC Cancer, vol. 9, 406. https://doi.org/10.1186/1471-2407-9-406

TY - JOUR

T1 - The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population

T2 - A case-control study

AU - Castillejo, Adela

AU - Mata-Balaguer, Trinidad

AU - Guarinos, Carla

AU - Castillejo, María Isabel

AU - Martínez-Cantó, Ana

AU - Barberá, Víctor Manuel

AU - Montenegro, Paola

AU - Ochoa, Enrique

AU - Lázaro, Rafael

AU - Guillén-Ponce, Carmen

AU - Carrato, Alfredo

AU - Soto, José Luís

N1 - Funding Information: This action has been performed within the cooperation framework established by the Transversal Cancer Action approved by the Council of Ministers on October 11th 2007 in accordance with the agreement between The Carlos III Health Institute (ISCIII), which is an autonomous entity currently belonging to the Ministry of Science and Innovation, and the Biomedical Research Foundation from the Hospital of Elche. Research supported in part by grants from the Generalitat Valenciana in Spain (AP106/06) and the Biomedical Research Foundation from the Hospital of Elche, Spain (FIBElx-02/2007). T.M-B is recipient of a fellowship from the Spanish Society of Medical Oncology (SEOM).

PY - 2009/11/20

Y1 - 2009/11/20

N2 - Background: The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1) has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC) has not been established. The aims of this study were to assess the association of TGFBR1*Int7G24A variant with CRC occurrence, patient age, gender, tumour location and stage. Methods: We performed a case-control study with 504 cases of sporadic CRC; and 504 non-cancerous age, gender and ethnically matched controls. Genotyping analysis was performed using allelic discrimination assay by real time PCR. Results: The Int7G24A variant was associated with increased CRC incidence in an additive model of inheritance (P for trend = 0.005). No significant differences were found between Int7G24A genotypes and tumour location or stage. Interestingly, the association of the Int7G24A variant with CRC risk was significant in men (odds ratio 4.10 with 95% confidence intervals 1.41-11.85 for homozygous individuals; P for trend = 0.00023), but not in women. We also observed an increase in susceptibility to CRC for individuals aged less than 70 years. Conclusion: Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population.

AB - Background: The Int7G24A variant of transforming growth factor-beta receptor type I (TGFBR1) has been shown to increase the risk for kidney, ovarian, bladder, lung and breast cancers. Its role in colorectal cancer (CRC) has not been established. The aims of this study were to assess the association of TGFBR1*Int7G24A variant with CRC occurrence, patient age, gender, tumour location and stage. Methods: We performed a case-control study with 504 cases of sporadic CRC; and 504 non-cancerous age, gender and ethnically matched controls. Genotyping analysis was performed using allelic discrimination assay by real time PCR. Results: The Int7G24A variant was associated with increased CRC incidence in an additive model of inheritance (P for trend = 0.005). No significant differences were found between Int7G24A genotypes and tumour location or stage. Interestingly, the association of the Int7G24A variant with CRC risk was significant in men (odds ratio 4.10 with 95% confidence intervals 1.41-11.85 for homozygous individuals; P for trend = 0.00023), but not in women. We also observed an increase in susceptibility to CRC for individuals aged less than 70 years. Conclusion: Our data suggest that the Int7G24A variant represents a risk factor for CRC in the male Spanish population.

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U2 - 10.1186/1471-2407-9-406

DO - 10.1186/1471-2407-9-406

M3 - Artículo

C2 - 19930569

AN - SCOPUS:71549140359

SN - 1471-2407

VL - 9

JO - BMC Cancer

JF - BMC Cancer

M1 - 406

ER -

The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: A case-control study

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