The Relationship between Latent Tuberculosis Infection and Acute Myocardial Infarction

Moises A. Huaman, Eduardo Ticona, Gustavo Miranda, Richard J. Kryscio, Raquel Mugruza, Ernesto Aranda, Paola L. Rondan, David Henson, Cesar Ticona, Timothy R. Sterling, Carl J. Fichtenbaum, Beth A. Garvy

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Background. Tuberculosis has been associated with an increased risk of cardiovascular disease (CVD), including acute myocardial infarction (AMI). We investigated whether latent tuberculosis infection (LTBI) is associated with AMI. Methods. We conducted a case-control study in 2 large national public hospital networks in Lima, Peru, between July 2015 and March 2017. Case patients were patients with a frst time diagnosis of type 1 (spontaneous) AMI. Controls were patients without a history of AMI. We excluded patients with known human immunodefciency virus infection, tuberculosis disease, or prior LTBI treatment. We used the QuantiFERON-TB Gold In-Tube assay to identify LTBI. We used logistic regression modeling to estimate the odds ratio (OR) of LTBI in AMI case patients versus non-AMI controls. Results. We enrolled 105 AMI case patients and 110 non-AMI controls during the study period. Overall, the median age was 62 years (interquartile range, 56-70 years); 69% of patients were male; 64% had hypertension, 40% dyslipidemia, and 39% diabetes mellitus; 30% used tobacco; and 24% were obese. AMI case patients were more likely than controls to be male (80% vs 59%; P <.01) and tobacco users (41% vs 20%; P <.01). LTBI was more frequent in AMI case patients than in controls (64% vs 49% [P =.03]; OR, 1.86; 95% confdence interval [CI], 1.08-3.22). Afer adjustment for age, sex, hypertension, dyslipidemia, diabetes mellitus, tobacco use, obesity, and family history of coronary artery disease, LTBI remained independently associated with AMI (adjusted OR, 1.90; 95% CI, 1.05-3.45). Conclusions. LTBI was independently associated with AMI. Our results suggest a potentially important role of LTBI in CVD.

Original languageEnglish
Pages (from-to)886-892
Number of pages7
JournalClinical Infectious Diseases
Volume66
Issue number6
DOIs
StatePublished - 5 Mar 2018

Bibliographical note

Funding Information:
Financial support. This work was supported in part by the University of Cincinnati Department of Internal Medicine (Junior Faculty Pilot Award) and the National Center for Research Resources and National Center for Advancing Translational Sciences, National Institutes of Health (grant UL1TR000117 to the University of Kentucky Center for Clinical and Translational Science).

Funding Information:
This work was supported in part by the University of Cincinnati Department of Internal Medicine (Junior Faculty Pilot Award) and the National Center for Research Resources and National Center for Advancing Translational Sciences, National Institutes of Health (grant UL1TR000117 to the University of Kentucky Center for Clinical and Translational Science).

Publisher Copyright:
© 2017 The Author(s).

Keywords

  • acute myocardial infarction
  • cardiovascular disease
  • latent tuberculosis infection
  • tuberculosis

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