TY - JOUR
T1 - Tracing the genomic ancestry of Peruvians reveals a major legacy of pre-Columbian ancestors
AU - Sandoval, Jose R.
AU - Salazar-Granara, Alberto
AU - Acosta, Oscar
AU - Castillo-Herrera, Wilder
AU - Fujita, Ricardo
AU - Pena, Sergio D.J.
AU - Santos, Fabricio R.
PY - 2013/9
Y1 - 2013/9
N2 - In order to investigate the underlying genetic structure and genomic ancestry proportions of Peruvian subpopulations, we analyzed 551 human samples of 25 localities from the Andean, Amazonian, and Coastal regions of Peru with a set of 40 ancestry informative insertion-deletion polymorphisms. Using genotypes of reference populations from different continents for comparison, our analysis indicated that populations from all 25 Peruvian locations had predominantly Amerindian genetic ancestry. Among populations from the Titicaca Lake islands of Taquile, Amantani, Anapia, and Uros, and the Yanque locality from the southern Peruvian Andes, there was no significant proportion of non-autochthonous genomes, indicating that their genetic background is effectively derived from the first settlers of South America. However, the Andean populations from San Marcos, Cajamarca, Characato and Chogo, and coastal populations from Lambayeque and Lima displayed a low but significant European ancestry proportion. Furthermore, Amazonian localities of Pucallpa, Lamas, Chachapoyas, and Andean localities of Ayacucho and Huancayo displayed intermediate levels of non-autochthonous ancestry, mostly from Europe. These results are in close agreement with the documented history of post-Columbian immigrations in Peru and with several reports suggesting a larger effective size of indigenous inhabitants during the formation of the current country's population.
AB - In order to investigate the underlying genetic structure and genomic ancestry proportions of Peruvian subpopulations, we analyzed 551 human samples of 25 localities from the Andean, Amazonian, and Coastal regions of Peru with a set of 40 ancestry informative insertion-deletion polymorphisms. Using genotypes of reference populations from different continents for comparison, our analysis indicated that populations from all 25 Peruvian locations had predominantly Amerindian genetic ancestry. Among populations from the Titicaca Lake islands of Taquile, Amantani, Anapia, and Uros, and the Yanque locality from the southern Peruvian Andes, there was no significant proportion of non-autochthonous genomes, indicating that their genetic background is effectively derived from the first settlers of South America. However, the Andean populations from San Marcos, Cajamarca, Characato and Chogo, and coastal populations from Lambayeque and Lima displayed a low but significant European ancestry proportion. Furthermore, Amazonian localities of Pucallpa, Lamas, Chachapoyas, and Andean localities of Ayacucho and Huancayo displayed intermediate levels of non-autochthonous ancestry, mostly from Europe. These results are in close agreement with the documented history of post-Columbian immigrations in Peru and with several reports suggesting a larger effective size of indigenous inhabitants during the formation of the current country's population.
KW - Admixture
KW - Colonization history
KW - Genomic ancestry
KW - INDELs
KW - Peru
KW - Population structure
KW - Pre-Columbian legacy
UR - http://www.scopus.com/inward/record.url?scp=84886668416&partnerID=8YFLogxK
U2 - 10.1038/jhg.2013.73
DO - 10.1038/jhg.2013.73
M3 - Artículo
C2 - 23863748
AN - SCOPUS:84886668416
SN - 1434-5161
VL - 58
SP - 627
EP - 634
JO - Journal of Human Genetics
JF - Journal of Human Genetics
IS - 9
ER -