Treatment of multidrug-resistant tuberculosis during pregnancy: A report of 7 cases

Sonya Shin, Dalia Guerra, Michael Rich, Kwonjune J. Seung, Joia Mukherjee, Keith Joseph, Rocio Hurtado, Felix Alcantara, Jaime Bayona, Cesar Bonilla, Paul Farmer, Jennifer Furin

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Multidrug-resistant tuberculosis (MDR-TB) is a global public health problem affecting women of childbearing age. Little is known, however, about the safety of the drugs used to treat MDR-TB during pregnancy. We describe 7 patients who were treated for MDR-TB during pregnancy. These patients had chronic tuberculosis that had caused extensive parenchymal damage and had high-grade resistance to antituberculous drugs. All patients received individualized antituberculous therapy prior to delivery of healthy term infants. Neither obstetrical complications nor perinatal transmission of MDB-TB was observed. One patient experienced treatment failure, and another abandoned therapy. The other 5 patients are currently cured or in treatment and have culture-negative status. In each of these 7 cases, excellent treatment outcomes were obtained for the women and their children. Under certain circumstances, MDR-TB can be successfully treated during pregnancy.
Original languageAmerican English
Pages (from-to)996-1003
Number of pages8
JournalClinical Infectious Diseases
DOIs
StatePublished - 15 Apr 2003
Externally publishedYes

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    Shin, S., Guerra, D., Rich, M., Seung, K. J., Mukherjee, J., Joseph, K., Hurtado, R., Alcantara, F., Bayona, J., Bonilla, C., Farmer, P., & Furin, J. (2003). Treatment of multidrug-resistant tuberculosis during pregnancy: A report of 7 cases. Clinical Infectious Diseases, 996-1003. https://doi.org/10.1086/374225