Treatment of neurocysticercosis: Current status and future research needs

T. E. Nash, G. Singh, A. C. White, V. Rajshekhar, J. A. Loeb, J. V. Proaño, O. M. Takayanagui, A. E. Gonzalez, J. A. Butman, C. DeGiorgio, O. H. Del Brutto, A. Delgado-Escueta, C. A.W. Evans, R. H. Gilman, S. M. Martinez, M. T. Medina, E. J. Pretell, J. Teale, H. H. Garcia

Research output: Contribution to journalReview articlepeer-review

144 Scopus citations

Abstract

Here we put forward a roadmap that summarizes important questions that need to be answered to determine more effective and safer treatments. A key concept in management of neurocysticercosis is the understanding that infection and disease due to neurocysticercosis are variable and thus different clinical approaches and treatments are required. Despite recent advances, treatments remain either suboptimal or based on poorly controlled or anecdotal experience. A better understanding of basic pathophysiologic mechanisms including parasite survival and evolution, nature of the inflammatory response, and the genesis of seizures, epilepsy, and mechanisms of anthelmintic action should lead to improved therapies.

Original languageEnglish
Pages (from-to)1120-1127
Number of pages8
JournalNeurology
Volume67
Issue number7
DOIs
StatePublished - Oct 2006

Bibliographical note

Funding Information:
Supported by the Office of Rare Diseases (NIH), National Institute of Allergy and Infectious Diseases/Laboratory of Parasitic Diseases (NIH), Universidad Peruana Cayetano Heredia (Lima, Peru), and Instituto de Ciencias Neurologicas (Lima, Peru).

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