Tumor necrosis factor-α soluble receptor p55 (sTNFp55) and risk of preeclampsia in Peruvian women

Sixto E. Sanchez, Cuilin Zhang, Michelle A. Williams, Suzie Ware-Jauregui, Gloria Tarcila Larrabure Torrealva, Victor Bazul, Allen Farrand

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22 Scopus citations

Abstract

We conducted a large case-control study to assess the risk of preeclampsia with elevated sTNFp55 concentrations (markers of excessive TNF-α release) in Peruvian women. A total of 125 women with preeclampsia and 179 normotensive women were included in a study conducted during the period, June 1997 through January 1998. Antepartum (third-trimester) plasma sTNFp55 was measured by enzyme linked immunosorbent assay. Mean plasma sTNFp55 concentrations were 32.4% higher among preeclampsia cases (920.1±30.4 pg/ml) as compared with controls (694.8±15.0 pg/ml, Student's t-test P<0.001). There was a strong linear increase in risk of preeclampsia with increasing concentrations of sTNFp55 (linear trend P-value <0.001). After adjusting for confounding factors, women in the highest quartile experienced a 10-fold increased risk of preeclampsia as compared with women in the lowest quartile (adjusted odds ratio, 10.3; 95% confidence interval, 4.1-25.9). Compared with women in the highest quartile, women in the second and third quartiles experienced a 3-fold or greater increased risk of preeclampsia (adjusted odds ratios were 3.1 and 3.8, respectively). Excessive TNF-α release (as measured by the detection of the soluble receptor sTNFp55 in maternal plasma collected before delivery) is increased in pregnancies complicated by preeclampsia as compared with normotensive pregnancies. These findings are consistent with most previous studies. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)49-63
Number of pages15
JournalJournal of Reproductive Immunology
Volume47
Issue number1
DOIs
StatePublished - May 2000
Externally publishedYes

Bibliographical note

Funding Information:
This research was supported by awards from the National Institutes of Health, T37-TW00049; HD/HL R01- 34888; HD R01 32562 and NCI P-30-15704. The authors wish to thank Nelly Toledo, Mirtha Grande, Elena Sanchez, Hong Tang, and Mohammed Adem, for their skillful technical assistance. We are also indebted to Dr Elizabeth T. Leary for performing the lipid analyses.

Keywords

  • Cytokines
  • Peru
  • Preeclampsia
  • Pregnancy
  • Soluble receptors
  • Tumor necrosis factor-α

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