Tumour cells resistance in cancer therapy

Isabel Martínez-Lacaci, Pilar GarcÍa Morales, Jos É Luis Soto, Miguel Saceda

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Resistance to chemotherapeutic drugs presents a big caveat for cancer treatment. In this review we will describe the molecular mechanisms involved in chemoresistance, discussing the mechanisms of resistance related to tumour microenvironment, as well as their intracellular mechanisms. Chemoresistance can also appear as a consequence to treatments with new anticancer drugs. In this sense, we will exemplify this type of resistance discussing mechanisms of action of epidermal growth factor receptor (EGFR) inhibitors. We conclude that the main problem of chemoresistance is due to its pleiotropic and multifactorial nature. © Springer-VerlagItalia 2007.
Original languageAmerican English
Pages (from-to)13-20
Number of pages8
JournalClinical and Translational Oncology
DOIs
StatePublished - 1 Jan 2007
Externally publishedYes

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