Tumour cells resistance in cancer therapy

Isabel Martínez-Lacaci, Pilar GarcÍa Morales, Jos É Luis Soto, Miguel Saceda

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Resistance to chemotherapeutic drugs presents a big caveat for cancer treatment. In this review we will describe the molecular mechanisms involved in chemoresistance, discussing the mechanisms of resistance related to tumour microenvironment, as well as their intracellular mechanisms. Chemoresistance can also appear as a consequence to treatments with new anticancer drugs. In this sense, we will exemplify this type of resistance discussing mechanisms of action of epidermal growth factor receptor (EGFR) inhibitors. We conclude that the main problem of chemoresistance is due to its pleiotropic and multifactorial nature.

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalClinical and Translational Oncology
Issue number1
StatePublished - 2007
Externally publishedYes

Bibliographical note

Funding Information:
*Supported by an unrestricted educational grant from Pfizer.


  • Apoptosis
  • Chemoresistance
  • MDR


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