Tumour cells resistance in cancer therapy

Isabel Martínez-Lacaci, Pilar GarcÍa Morales, Jos É Luis Soto, Miguel Saceda

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Resistance to chemotherapeutic drugs presents a big caveat for cancer treatment. In this review we will describe the molecular mechanisms involved in chemoresistance, discussing the mechanisms of resistance related to tumour microenvironment, as well as their intracellular mechanisms. Chemoresistance can also appear as a consequence to treatments with new anticancer drugs. In this sense, we will exemplify this type of resistance discussing mechanisms of action of epidermal growth factor receptor (EGFR) inhibitors. We conclude that the main problem of chemoresistance is due to its pleiotropic and multifactorial nature.

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalClinical and Translational Oncology
Volume9
Issue number1
DOIs
StatePublished - 2007

Bibliographical note

Funding Information:
*Supported by an unrestricted educational grant from Pfizer.

Keywords

  • Apoptosis
  • Chemoresistance
  • MDR

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