Tumour cells resistance in cancer therapy

Isabel Martínez-Lacaci; Pilar GarcÍa Morales; Jos É Luis Soto; Miguel Saceda

doi:10.1007/s12094-007-0004-9

Tumour cells resistance in cancer therapy

Isabel Martínez-Lacaci, Pilar GarcÍa Morales, Jos É Luis Soto, Miguel Saceda

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Resistance to chemotherapeutic drugs presents a big caveat for cancer treatment. In this review we will describe the molecular mechanisms involved in chemoresistance, discussing the mechanisms of resistance related to tumour microenvironment, as well as their intracellular mechanisms. Chemoresistance can also appear as a consequence to treatments with new anticancer drugs. In this sense, we will exemplify this type of resistance discussing mechanisms of action of epidermal growth factor receptor (EGFR) inhibitors. We conclude that the main problem of chemoresistance is due to its pleiotropic and multifactorial nature.

Original language	English
Pages (from-to)	13-20
Number of pages	8
Journal	Clinical and Translational Oncology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1007/s12094-007-0004-9
State	Published - 2007
Externally published	Yes

Bibliographical note

Funding Information:
*Supported by an unrestricted educational grant from Pfizer.

Keywords

Apoptosis
Chemoresistance
MDR

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10.1007/s12094-007-0004-9

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title = "Tumour cells resistance in cancer therapy",

abstract = "Resistance to chemotherapeutic drugs presents a big caveat for cancer treatment. In this review we will describe the molecular mechanisms involved in chemoresistance, discussing the mechanisms of resistance related to tumour microenvironment, as well as their intracellular mechanisms. Chemoresistance can also appear as a consequence to treatments with new anticancer drugs. In this sense, we will exemplify this type of resistance discussing mechanisms of action of epidermal growth factor receptor (EGFR) inhibitors. We conclude that the main problem of chemoresistance is due to its pleiotropic and multifactorial nature.",

keywords = "Apoptosis, Chemoresistance, MDR",

author = "Isabel Mart{\'i}nez-Lacaci and {Garc{\'I}a Morales}, Pilar and Soto, {Jos {\'E} Luis} and Miguel Saceda",

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year = "2007",

doi = "10.1007/s12094-007-0004-9",

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T1 - Tumour cells resistance in cancer therapy

AU - Martínez-Lacaci, Isabel

AU - GarcÍa Morales, Pilar

AU - Soto, Jos É Luis

AU - Saceda, Miguel

N1 - Funding Information: *Supported by an unrestricted educational grant from Pfizer.

PY - 2007

Y1 - 2007

N2 - Resistance to chemotherapeutic drugs presents a big caveat for cancer treatment. In this review we will describe the molecular mechanisms involved in chemoresistance, discussing the mechanisms of resistance related to tumour microenvironment, as well as their intracellular mechanisms. Chemoresistance can also appear as a consequence to treatments with new anticancer drugs. In this sense, we will exemplify this type of resistance discussing mechanisms of action of epidermal growth factor receptor (EGFR) inhibitors. We conclude that the main problem of chemoresistance is due to its pleiotropic and multifactorial nature.

AB - Resistance to chemotherapeutic drugs presents a big caveat for cancer treatment. In this review we will describe the molecular mechanisms involved in chemoresistance, discussing the mechanisms of resistance related to tumour microenvironment, as well as their intracellular mechanisms. Chemoresistance can also appear as a consequence to treatments with new anticancer drugs. In this sense, we will exemplify this type of resistance discussing mechanisms of action of epidermal growth factor receptor (EGFR) inhibitors. We conclude that the main problem of chemoresistance is due to its pleiotropic and multifactorial nature.

KW - Apoptosis

KW - Chemoresistance

KW - MDR

UR - http://www.scopus.com/inward/record.url?scp=34249021632&partnerID=8YFLogxK

U2 - 10.1007/s12094-007-0004-9

DO - 10.1007/s12094-007-0004-9

M3 - Artículo

C2 - 17272225

AN - SCOPUS:34249021632

SN - 1699-048X

VL - 9

SP - 13

EP - 20

JO - Clinical and Translational Oncology

JF - Clinical and Translational Oncology

IS - 1

ER -

Tumour cells resistance in cancer therapy

Abstract

Bibliographical note

Keywords

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