Understanding Risk Factors for Poor Outcomes in a Multiethnic Longitudinal Cohort: The LUMINA (Lupus in Minorities: Nature vs. Nurture) Experience (LUMINA LXXXII)

Luis Alonso González, Guillermo J. Pons-Estel, Sergio M.A. Toloza, Manuel Francisco Ugarte Gil, Graciela S. Alarcón

Research output: Contribution to journalReview articlepeer-review

Abstract

The Lupus in Minorities: Nature Vs Nurture (LUMINA) cohort has placed Hispanics on the lupus map in the United States. Texan Hispanic and African American patients experience, overall, worse outcomes than the Caucasian and Puerto Rican Hispanic patients. The genetic component of ethnicity is important early in the disease course whereas socioeconomic factors become more important subsequently. The role of hydroxychloroquine in preventing damage accrual and reducing mortality in lupus patients is a major contribution of LUMINA.

Original languageEnglish
Pages (from-to)55-64
Number of pages10
JournalRheumatic Disease Clinics of North America
Volume47
Issue number1
DOIs
StatePublished - Feb 2021
Externally publishedYes

Keywords

  • Disease activity
  • Disparities
  • Ethnicity
  • LUMINA
  • Lupus
  • Mortality
  • Quality of life
  • Systemic lupus erythematosus

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