Validation of a spatial agent-based model for taenia solium transmission (“cystiagent”) against a large prospective trial of control strategies in northern Peru

Ian W. Pray, Francesco Pizzitutti, Gabrielle Bonnet, Eloy Gonzales-Gustavson, Wayne Wakeland, William K. Pan, William E. Lambert, Armando E. Gonzalez, Hector H. Garcia, Seth E. O’neal

Research output: Contribution to journalArticlepeer-review

Abstract

Background The pork tapeworm (Taenia solium) is a parasitic helminth that imposes a major health and economic burden on poor rural populations around the world. As recognized by the World Health Organization, a key barrier for achieving control of T. solium is the lack of an accurate and validated simulation model with which to study transmission and evaluate available control and elimination strategies. CystiAgent is a spatially-explicit agent based model for T. solium that is unique among T. solium models in its ability to represent key spatial and environmental features of transmission and simulate spatially targeted interventions, such as ring strategy. Methods/Principal findings We validated CystiAgent against results from the Ring Strategy Trial (RST)–a large cluster-randomized trial conducted in northern Peru that evaluated six unique interventions for T. solium control in 23 villages. For the validation, each intervention strategy was replicated in CystiAgent, and the simulated prevalences of human taeniasis, porcine cysticercosis, and porcine seroincidence were compared against prevalence estimates from the trial. Results showed that CystiAgent produced declines in transmission in response to each of the six intervention strategies, but overestimated the effect of interventions in the majority of vil-lages; simulated prevalences for human taenasis and porcine cysticercosis at the end of the trial were a median of 0.53 and 5.0 percentages points less than prevalence observed at the end of the trial, respectively. Conclusions/Significance The validation of CystiAgent represented an important step towards developing an accurate and reliable T. solium transmission model that can be deployed to fill critical gaps in our understanding of T. solium transmission and control. To improve model accuracy, future versions would benefit from improved data on pig immunity and resistance, field effective-ness of anti-helminthic treatment, and factors driving spatial clustering of T. solium infections including dispersion and contact with T. solium eggs in the environment.

Original languageEnglish
Article numbere0009885
JournalPLoS Neglected Tropical Diseases
Volume15
Issue number10
DOIs
StatePublished - Oct 2021

Bibliographical note

Funding Information:
This research was funded in part by the US National Institute of Allergy and Infectious Disease (R01AI141554), the National Institute of Neurologic Disorders and Stroke (R01NS080645), and the Fogarty International Center through the National Institutes of Health. Grants were awarded to SEO as principal investigator. SEO, FP, GB, EGG, WP, AEG and HHG receive salary through these grants. IWP was supported with travel and stipend for doctoral work by the Fulbright US Students Program and Fulbright Commission in Peru. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2021 Pray et al.

Fingerprint

Dive into the research topics of 'Validation of a spatial agent-based model for taenia solium transmission (“cystiagent”) against a large prospective trial of control strategies in northern Peru'. Together they form a unique fingerprint.

Cite this