Voltammetric determination of thiomersal with a new modified electrode based on a carbon paste electrode decorated with La2O3

Johisner Penagos-Llanos, Jorge A. Calderón, Edgar Orlando Nagles Vidal, Jhon J. Hurtado

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A carbon-paste modified electrode decorated with La2O3 (LaOx/CPE) is reported for the first time for the voltammetric determination of thiomersal (THM) content. The LaOx/CPE surface was characterized using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM). The presence of La2O3 on the surface of the carbon paste reduces the charge transfer resistance and improves the sensitivity toward the oxidation of THM, with an oxidation current increase of almost 60% and allows its determination by square-wave stripping voltammetry (SWSV). The detection limit (3σ/b) was 0.09 μmol L−1 and the relative standard deviation was 2.5% (n = 7) with three different electrodes. Furthermore, the new sensor was applied in the detection of THM in vaccines and pharmaceutical dosages.

Original languageEnglish
Pages (from-to)536-542
Number of pages7
JournalJournal of Electroanalytical Chemistry
Volume833
DOIs
StatePublished - 15 Jan 2019
Externally publishedYes

Bibliographical note

Funding Information:
The authors thank the Universidad de Ibagué (18-541-INT) and the Department of Chemistry and the School of Science of the Universidad de los Andes for the financial support.

Keywords

  • Carbon paste
  • Lanthanum (III) oxide
  • Square wave stripping voltammetry
  • Thiomersal
  • Vaccines

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