2021 DORIS definition of remission in SLE: Final recommendations from an international task force

Ronald F. van Vollenhoven; George Bertsias; Andrea Doria; David Isenberg; Eric Morand; Michelle A. Petri; Bernardo A. Pons-Estel; Anisur Rahman; Manuel Francisco Ugarte-Gil; Alexandre Voskuyl; Laurent Arnaud; Ian N. Bruce; Ricard Cervera; Nathalie Costedoat-Chalumeau; Caroline Gordon; Frédéric A. Houssiau; Marta Mosca; Matthias Schneider; Michael M. Ward; Graciela Alarcon; Martin Aringer; Anka Askenase; Sang Cheol Bae; Hendrika Bootsma; Dimitrios T. Boumpas; Hermine Brunner; Ann Elaine Clarke; Cindy Coney; László Czirják; Thomas Dörner; Raquel Faria; Rebecca Fischer; Ruth Fritsch-Stork; Murat Inanc; Søren Jacobsen; David Jayne; Annegret Kuhn; Bernadette van Leeuw; Maarten Limper; Xavier Mariette; Sandra Navarra; Mandana Nikpour; Marzena Helena Olesinska; Guillermo Pons-Estel; Juanita Romero-Diaz; Blanca Rubio; Yehuda Schoenfeld; Eloisa Bonfá; Josef Smolen; Y. K.Onno Teng; Angela Tincani; Michel Tsang-A-Sjoe; Carlos Vasconcelos; Anne Voss; Victoria P. Werth; Elena Zakharhova; Cynthia Aranow

doi:10.1136/lupus-2021-000538

2021 DORIS definition of remission in SLE: Final recommendations from an international task force

Ronald F. van Vollenhoven, George Bertsias, Andrea Doria, David Isenberg, Eric Morand, Michelle A. Petri, Bernardo A. Pons-Estel, Anisur Rahman, Manuel Francisco Ugarte-Gil, Alexandre Voskuyl, Laurent Arnaud, Ian N. Bruce, Ricard Cervera, Nathalie Costedoat-Chalumeau, Caroline Gordon, Frédéric A. Houssiau, Marta Mosca, Matthias Schneider, Michael M. Ward, Graciela AlarconMartin Aringer, Anka Askenase, Sang Cheol Bae, Hendrika Bootsma, Dimitrios T. Boumpas, Hermine Brunner, Ann Elaine Clarke, Cindy Coney, László Czirják, Thomas Dörner, Raquel Faria, Rebecca Fischer, Ruth Fritsch-Stork, Murat Inanc, Søren Jacobsen, David Jayne, Annegret Kuhn, Bernadette van Leeuw, Maarten Limper, Xavier Mariette, Sandra Navarra, Mandana Nikpour, Marzena Helena Olesinska, Guillermo Pons-Estel, Juanita Romero-Diaz, Blanca Rubio, Yehuda Schoenfeld, Eloisa Bonfá, Josef Smolen, Y. K.Onno Teng, Angela Tincani, Michel Tsang-A-Sjoe, Carlos Vasconcelos, Anne Voss, Victoria P. Werth, Elena Zakharhova, Cynthia Aranow

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144 Citas (Scopus)

Resumen

Objective To achieve consensus on a definition of remission in SLE (DORIS). Background Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation. Methods Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on. Results Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator’s Global Assessment <0.5 (0–3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics. Conclusion The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.

Idioma original	Inglés
Número de artículo	e000538
Publicación	Lupus Science and Medicine
Volumen	8
N.º	1
DOI	https://doi.org/10.1136/lupus-2021-000538
Estado	Publicada - 24 nov. 2021

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van Vollenhoven, R. F., Bertsias, G., Doria, A., Isenberg, D., Morand, E., Petri, M. A., Pons-Estel, B. A., Rahman, A., Ugarte-Gil, M. F., Voskuyl, A., Arnaud, L., Bruce, I. N., Cervera, R., Costedoat-Chalumeau, N., Gordon, C., Houssiau, F. A., Mosca, M., Schneider, M., Ward, M. M., ... Aranow, C. (2021). 2021 DORIS definition of remission in SLE: Final recommendations from an international task force. Lupus Science and Medicine, 8(1), Artículo e000538. https://doi.org/10.1136/lupus-2021-000538

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title = "2021 DORIS definition of remission in SLE: Final recommendations from an international task force",

abstract = "Objective To achieve consensus on a definition of remission in SLE (DORIS). Background Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation. Methods Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on. Results Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator{\textquoteright}s Global Assessment <0.5 (0–3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics. Conclusion The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.",

author = "{van Vollenhoven}, {Ronald F.} and George Bertsias and Andrea Doria and David Isenberg and Eric Morand and Petri, {Michelle A.} and Pons-Estel, {Bernardo A.} and Anisur Rahman and Ugarte-Gil, {Manuel Francisco} and Alexandre Voskuyl and Laurent Arnaud and Bruce, {Ian N.} and Ricard Cervera and Nathalie Costedoat-Chalumeau and Caroline Gordon and Houssiau, {Fr{\'e}d{\'e}ric A.} and Marta Mosca and Matthias Schneider and Ward, {Michael M.} and Graciela Alarcon and Martin Aringer and Anka Askenase and Bae, {Sang Cheol} and Hendrika Bootsma and Boumpas, {Dimitrios T.} and Hermine Brunner and Clarke, {Ann Elaine} and Cindy Coney and L{\'a}szl{\'o} Czirj{\'a}k and Thomas D{\"o}rner and Raquel Faria and Rebecca Fischer and Ruth Fritsch-Stork and Murat Inanc and S{\o}ren Jacobsen and David Jayne and Annegret Kuhn and {van Leeuw}, Bernadette and Maarten Limper and Xavier Mariette and Sandra Navarra and Mandana Nikpour and Olesinska, {Marzena Helena} and Guillermo Pons-Estel and Juanita Romero-Diaz and Blanca Rubio and Yehuda Schoenfeld and Eloisa Bonf{\'a} and Josef Smolen and Teng, {Y. K.Onno} and Angela Tincani and Michel Tsang-A-Sjoe and Carlos Vasconcelos and Anne Voss and Werth, {Victoria P.} and Elena Zakharhova and Cynthia Aranow",

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doi = "10.1136/lupus-2021-000538",

language = "Ingl{\'e}s",

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van Vollenhoven, RF, Bertsias, G, Doria, A, Isenberg, D, Morand, E, Petri, MA, Pons-Estel, BA, Rahman, A, Ugarte-Gil, MF, Voskuyl, A, Arnaud, L, Bruce, IN, Cervera, R, Costedoat-Chalumeau, N, Gordon, C, Houssiau, FA, Mosca, M, Schneider, M, Ward, MM, Alarcon, G, Aringer, M, Askenase, A, Bae, SC, Bootsma, H, Boumpas, DT, Brunner, H, Clarke, AE, Coney, C, Czirják, L, Dörner, T, Faria, R, Fischer, R, Fritsch-Stork, R, Inanc, M, Jacobsen, S, Jayne, D, Kuhn, A, van Leeuw, B, Limper, M, Mariette, X, Navarra, S, Nikpour, M, Olesinska, MH, Pons-Estel, G, Romero-Diaz, J, Rubio, B, Schoenfeld, Y, Bonfá, E, Smolen, J, Teng, YKO, Tincani, A, Tsang-A-Sjoe, M, Vasconcelos, C, Voss, A, Werth, VP, Zakharhova, E & Aranow, C 2021, '2021 DORIS definition of remission in SLE: Final recommendations from an international task force', Lupus Science and Medicine, vol. 8, n.º 1, e000538. https://doi.org/10.1136/lupus-2021-000538

TY - JOUR

T1 - 2021 DORIS definition of remission in SLE

T2 - Final recommendations from an international task force

AU - van Vollenhoven, Ronald F.

AU - Bertsias, George

AU - Doria, Andrea

AU - Isenberg, David

AU - Morand, Eric

AU - Petri, Michelle A.

AU - Pons-Estel, Bernardo A.

AU - Rahman, Anisur

AU - Ugarte-Gil, Manuel Francisco

AU - Voskuyl, Alexandre

AU - Arnaud, Laurent

AU - Bruce, Ian N.

AU - Cervera, Ricard

AU - Costedoat-Chalumeau, Nathalie

AU - Gordon, Caroline

AU - Houssiau, Frédéric A.

AU - Mosca, Marta

AU - Schneider, Matthias

AU - Ward, Michael M.

AU - Alarcon, Graciela

AU - Aringer, Martin

AU - Askenase, Anka

AU - Bae, Sang Cheol

AU - Bootsma, Hendrika

AU - Boumpas, Dimitrios T.

AU - Brunner, Hermine

AU - Clarke, Ann Elaine

AU - Coney, Cindy

AU - Czirják, László

AU - Dörner, Thomas

AU - Faria, Raquel

AU - Fischer, Rebecca

AU - Fritsch-Stork, Ruth

AU - Inanc, Murat

AU - Jacobsen, Søren

AU - Jayne, David

AU - Kuhn, Annegret

AU - van Leeuw, Bernadette

AU - Limper, Maarten

AU - Mariette, Xavier

AU - Navarra, Sandra

AU - Nikpour, Mandana

AU - Olesinska, Marzena Helena

AU - Pons-Estel, Guillermo

AU - Romero-Diaz, Juanita

AU - Rubio, Blanca

AU - Schoenfeld, Yehuda

AU - Bonfá, Eloisa

AU - Smolen, Josef

AU - Teng, Y. K.Onno

AU - Tincani, Angela

AU - Tsang-A-Sjoe, Michel

AU - Vasconcelos, Carlos

AU - Voss, Anne

AU - Werth, Victoria P.

AU - Zakharhova, Elena

AU - Aranow, Cynthia

PY - 2021/11/24

Y1 - 2021/11/24

N2 - Objective To achieve consensus on a definition of remission in SLE (DORIS). Background Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation. Methods Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on. Results Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator’s Global Assessment <0.5 (0–3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics. Conclusion The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.

AB - Objective To achieve consensus on a definition of remission in SLE (DORIS). Background Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation. Methods Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on. Results Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator’s Global Assessment <0.5 (0–3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics. Conclusion The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.

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DO - 10.1136/lupus-2021-000538

M3 - Artículo de revisión

AN - SCOPUS:85121234911

SN - 2053-8790

VL - 8

JO - Lupus Science and Medicine

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ER -

2021 DORIS definition of remission in SLE: Final recommendations from an international task force

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