A robust H8 control approach for blood glucose regulation in type-1 diabetes

The paper addresses the design of a H8 closed-loop dedicated to Blood Glucose (BG) regulation for patients affected by Type-1 Diabetes Mellitus (T1DM). The closed-loop setup is standard, i.e. the H8 feedback controller uses the information provided by a subcutaneous sensor to drive an insulin pump but as opposed to current existing solutions, it is proposed to assess the capabilities of a H8 controller to be designed in a patient-independent way. For that purpose, the design is performed on a family of linear models in order to tackle the variability of a cohort of T1DM patients. Worst-case performance and robust margins are next computed with the help of the H8/µ-analysis theory. The solution is finally assessed on the adult cohort of the high-fidelity UVA/Padova benchmark (v3.2), accepted by the US Food and Drug Administration (FDA) as a substitute for pre-clinical testing of control strategies.