Angiotensin-receptor blockers and the risk of alzheimer´s disease: A meta-analysis

Teodoro J. Oscanoa, Jose Percy Amado Tineo, Xavier Vidal, Roman Romero-Ortuno

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva


Background: Anti-hypertensive medications may reduce the incidence of cognitive disorders. This may be due to reasons beyond their pure hypotensive effect. This study aimed to systematically review the association between the use of Angiotensin-Receptor Blockers (ARBs) and the incidence of Alzheimer’s disease (AD). Methods: We systematically searched studies reporting the association between ARB use and the incidence of AD. Results: Ten studies (1 RCT, 2 case-control and 7 cohort studies) met the inclusion criteria. When all observational studies (9) were analyzed, ARB use was associated with a reduced risk of incident AD (HR 0.72, 95% CI: 0.58-0.88, p<0.001). In the only RCT, decrease in the incidence of AD was also significant (HR= 0.31, 95% CI: 0.14-0.68). Conclusion: ARB use may reduce the risk of incident AD. This association does not imply causation and further research is required to clarify potential mechanisms.

Idioma originalInglés
Páginas (desde-hasta)73-78
Número de páginas6
PublicaciónCurrent Reviews in Clinical and Experimental Pharmacology
EstadoPublicada - 2021

Nota bibliográfica

Publisher Copyright:
© 2021 Bentham Science Publishers.


Profundice en los temas de investigación de 'Angiotensin-receptor blockers and the risk of alzheimer´s disease: A meta-analysis'. En conjunto forman una huella única.

Citar esto