TY - JOUR
T1 - Antimicrobial Susceptibility of Neisseria gonorrhoeae Isolates From Peru, 2018 and 2019
AU - Jorge-Berrocal, Ana
AU - Vargas-Herrera, Natalia
AU - Benites, Carlos
AU - Salazar-Quispe, Fabiola
AU - Mayta-Barrios, Maritza
AU - Barrios-Cárdenas, Yuli J.
AU - Melano, Roberto G.
AU - Yagui, Martin
AU - Eulogio Castro, M.
AU - Munive Guerrero, M. S.
AU - Tarazona Reyes, I.
AU - Dongo Rojas, E.
AU - Cucho Espinoza, C.
AU - Ticona Huaroto, C.
AU - Palomino Balbín, E.
AU - Chumbe Huauya, H.
AU - Gutierrez Rojas, M.
AU - Peralta Siesquén, C.
AU - Gónzales Bustamante, M. K.
AU - Cayuri Cabrera, M.
AU - De Paz Yara, M. D.
AU - Flores Andia, A.
AU - Gamboa Paredes, V.
AU - Miranda Mamani, J.
AU - Valdez Gallegos, B. F.
AU - Apaza Flores, A. I.
AU - Carranza Vilca, V.
AU - Tafur Gonzales, J. A.
AU - Sandoval Mesía, Y.
AU - Suyón Urquizo, J.
AU - Reyes Castro, V.
N1 - Publisher Copyright:
© Lippincott Williams & Wilkins.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - Background Currently, in Latin America, including Peru, the treatment of gonorrhea is still empiric and information regarding antimicrobial resistance is scarce in some countries because of the limited resources, which can contribute to the rising rates of reported multidrug-resistant gonococcal strains. In that context, it is mandatory to continuously monitor and report antimicrobial resistance in N. gonorrhoeae to update treatment recommendations. Methods This descriptive study analyzed genital and anal samples from symptomatic patients who attended 15 sexually transmitted infections health facilities from 8 different regions in Peru during the years 2018 to 2019 within the framework of Sentinel Surveillance. After establishing the presumptive diagnosis, the isolates were sent to the Laboratory of Sexually Transmitted Bacteria of the National Institute of Health of Peru in Lima where the species were confirmed (N = 165) and susceptibility profiles were determined. Results Among the 165 isolates, 95.2% corresponded to male patients, between 18 and 22 years of age (40.6%), half reported having a sexual partner and being heterosexual. Clinically, 89.7% manifested the presence of urethral exudate. Microbiology showed 95.2% of the isolates resistant to ciprofloxacin and 9.1% non-susceptible to azithromycin. Reduced susceptibility to ceftriaxone and cefixime was observed in 1.2% and 3.6% of the isolates respectively. All strains tested were susceptible to spectinomycin. Conclusions This study demonstrated that in Peru, fluoroquinolones should not be recommended or used in N. gonorrhoeae infections due to the high percentage of resistant strains. In addition, nationwide access to gonococcal resistance testing, molecular diagnostics and antimicrobial stewardship should be implemented to control the spread of gonococcal antimicrobial resistance.
AB - Background Currently, in Latin America, including Peru, the treatment of gonorrhea is still empiric and information regarding antimicrobial resistance is scarce in some countries because of the limited resources, which can contribute to the rising rates of reported multidrug-resistant gonococcal strains. In that context, it is mandatory to continuously monitor and report antimicrobial resistance in N. gonorrhoeae to update treatment recommendations. Methods This descriptive study analyzed genital and anal samples from symptomatic patients who attended 15 sexually transmitted infections health facilities from 8 different regions in Peru during the years 2018 to 2019 within the framework of Sentinel Surveillance. After establishing the presumptive diagnosis, the isolates were sent to the Laboratory of Sexually Transmitted Bacteria of the National Institute of Health of Peru in Lima where the species were confirmed (N = 165) and susceptibility profiles were determined. Results Among the 165 isolates, 95.2% corresponded to male patients, between 18 and 22 years of age (40.6%), half reported having a sexual partner and being heterosexual. Clinically, 89.7% manifested the presence of urethral exudate. Microbiology showed 95.2% of the isolates resistant to ciprofloxacin and 9.1% non-susceptible to azithromycin. Reduced susceptibility to ceftriaxone and cefixime was observed in 1.2% and 3.6% of the isolates respectively. All strains tested were susceptible to spectinomycin. Conclusions This study demonstrated that in Peru, fluoroquinolones should not be recommended or used in N. gonorrhoeae infections due to the high percentage of resistant strains. In addition, nationwide access to gonococcal resistance testing, molecular diagnostics and antimicrobial stewardship should be implemented to control the spread of gonococcal antimicrobial resistance.
UR - http://www.scopus.com/inward/record.url?scp=85138451508&partnerID=8YFLogxK
U2 - 10.1097/OLQ.0000000000001678
DO - 10.1097/OLQ.0000000000001678
M3 - Artículo
C2 - 35858477
AN - SCOPUS:85138451508
SN - 0148-5717
VL - 49
SP - 682
EP - 686
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
IS - 10
ER -
