Attempts to establish experimental Cyclospora cayetanensis infection in laboratory animals

Mark L. Eberhard, Ynes R. Ortega, Darcy E. Hanes, Eva K. Nace, Rose Quy Do, Martin G. Robl, Kimberly Y. Won, Cesar Gavidia, Neil L. Sass, Keith Mansfield, Alfonso Gozalo, Jeffrey Griffiths, Robert Gilman, Charles R. Sterling, Michael J. Arrowood

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

62 Citas (Scopus)

Resumen

Attempts were made to develop an animal model for Cyclospora cayetanensis to identify a practical laboratory host for studying human cyclosporiasis. Oocysts collected from stool of infected humans in the United States, Haiti, Guatemala, Peru, and Nepal were held in potassium dichromate solution to allow development of sporozoites. The following animal types were inoculated: 9 strains of mice, including adult and neonatal immunocompetent and immune-deficient inbred and outbred strains, rats, sandrats, chickens, ducks, rabbits, jirds, hamsters, ferrets, pigs, dogs, owl monkeys, rhesus monkeys, and cynomolgus monkeys. Most animals were inoculated by gavage, although some of the primates were fed oocysts on food items. The animals were examined for signs of infection, particularly diarrhea, and stool samples were examined for 4-6 wk after inoculation. None of the animals developed patent infections or signs of infection. We conclude that none of the animals tested is susceptible to infection with C. cayetanensis.

Idioma originalInglés
Páginas (desde-hasta)577-582
Número de páginas6
PublicaciónJournal of Parasitology
Volumen86
N.º3
DOI
EstadoPublicada - jun 2000

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