TY - JOUR
T1 - Carbohydrate metabolism in women receiving d-norgestrel for postcoital contraception+
AU - Garmendia Lorena, Fausto Anibal
AU - Urdanivia, E.
AU - Kesseru, E.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1979
Y1 - 1979
N2 - Under this type of contraceptive treatment subtle and not very striking responses were observed. An increase in fasting IRI and IRI response to glucose load, a decrease in fasting BG and no changes in NEFA or K-glucose values were the noted features. No significant weight gain was observed which could have explained the BG and IRI changes. These results are in agreement with other published data despite differences in experimental conditions. On the other hand we found a positive correlation between the IRI peaks and the number of pills ingested during the last menstrual cycle, which suggests a dose-related effect. Our data suggest that 300 μg of d-norgestrel administered postcoitally, slightly influence carbohydrate metabolism. It may be postulated that decreased insulin sensitivity by peripheral tissues leads to augmented IRI secretion in order to maintain glucose utilization at a normal rate.
AB - Under this type of contraceptive treatment subtle and not very striking responses were observed. An increase in fasting IRI and IRI response to glucose load, a decrease in fasting BG and no changes in NEFA or K-glucose values were the noted features. No significant weight gain was observed which could have explained the BG and IRI changes. These results are in agreement with other published data despite differences in experimental conditions. On the other hand we found a positive correlation between the IRI peaks and the number of pills ingested during the last menstrual cycle, which suggests a dose-related effect. Our data suggest that 300 μg of d-norgestrel administered postcoitally, slightly influence carbohydrate metabolism. It may be postulated that decreased insulin sensitivity by peripheral tissues leads to augmented IRI secretion in order to maintain glucose utilization at a normal rate.
UR - http://www.scopus.com/inward/record.url?scp=0018742554&partnerID=8YFLogxK
U2 - 10.1055/s-0028-1095760
DO - 10.1055/s-0028-1095760
M3 - Artículo
C2 - 428916
AN - SCOPUS:0018742554
VL - 11
SP - 81
EP - 82
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
SN - 0018-5043
IS - 1
ER -