TY - JOUR
T1 - Cervical shedding of human T cell lymphotropic virus type I is associated with cervicitis
AU - Zunt, Joseph R.
AU - Dezzutti, Charlene S.
AU - Montano, Silvia M.
AU - Thomas, Katherine K.
AU - Alarcón, Jorge O.V.
AU - Quijano, Eberth
AU - Courtois, Barry N.
AU - Sánchez, Jorge L.
AU - Campos, Pablo
AU - Gotuzzo, Eduardo
AU - Guenthner, Patricia C.
AU - Lal, Renu B.
AU - Holmes, King K.
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Human T cell lymphotropic virus type I (HTLV-I) is sexually transmitted. The purpose of this study was to determine the prevalence and risk factors for cervical shedding of HTLV-I DNA among Peruvian sex workers. HTLV tax DNA was detected in cervical specimens from 43 (68%) of 63 HTLV-I-infected sex workers and in samples obtained during 113 (52%) of 216 clinic visits between 1993 and 1997. Detection of HTLV DNA was associated with the presence of ≥30 polymorphonuclear cells (PMNs) within cervical mucus per 100X microscopic field (odds ratio [OR], 4.3, 95% confidence interval [CI], 1.8-10.1) and with the presence of cervical secretions (OR, 2.0; 95% CI 1.2-3.4). Hormonal contraceptive use (OR 1.7; 95% CI, 0.8-3.6) and concomitant cervical infection by Chlamydia trachomatis (OR, 1.5; 95% CI, 0.3-4.3) or Neisseria gonorrhoeae (OR, 1.1; 95% CI, 0.6-3.7) were not significantly associated with HTLV-I shedding. Our results suggest that cervicitis may increase cervical HTLV-I shedding and the sexual transmission of this virus.
AB - Human T cell lymphotropic virus type I (HTLV-I) is sexually transmitted. The purpose of this study was to determine the prevalence and risk factors for cervical shedding of HTLV-I DNA among Peruvian sex workers. HTLV tax DNA was detected in cervical specimens from 43 (68%) of 63 HTLV-I-infected sex workers and in samples obtained during 113 (52%) of 216 clinic visits between 1993 and 1997. Detection of HTLV DNA was associated with the presence of ≥30 polymorphonuclear cells (PMNs) within cervical mucus per 100X microscopic field (odds ratio [OR], 4.3, 95% confidence interval [CI], 1.8-10.1) and with the presence of cervical secretions (OR, 2.0; 95% CI 1.2-3.4). Hormonal contraceptive use (OR 1.7; 95% CI, 0.8-3.6) and concomitant cervical infection by Chlamydia trachomatis (OR, 1.5; 95% CI, 0.3-4.3) or Neisseria gonorrhoeae (OR, 1.1; 95% CI, 0.6-3.7) were not significantly associated with HTLV-I shedding. Our results suggest that cervicitis may increase cervical HTLV-I shedding and the sexual transmission of this virus.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0036890659&origin=inward
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=0036890659&origin=inward
U2 - 10.1086/345364
DO - 10.1086/345364
M3 - Article
SN - 0022-1899
SP - 1669
EP - 1672
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
ER -