Características clínicas de la hepatotoxicidad asociada a la pirazinamida en pacientes de un hospital de lima, perú

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

In order to determine the characteristics of drug-induced liver injury (DILI), adult patients diagnosed with tuberculosis and with an anti-tuberculosis treatment scheme including pyrazinamide were studied. The re-exposure process was used for the cause-effect analysis of the DILI. A total of 10 patients were found with pyrazinamide-associated DILI; the median age and hospital stay were 40.5 years (from 22 to 76 years) and 41 days (from 11 to 130 days), respectively. The median time in which the events appeared was 14 days (from 3 to 46 days); jaundice was observed in 4 patients and radiological patterns such as hepatocellular, mixed and cholestatic were found in 5, 3 and 2 patients, respectively. Mild presentation of DILI was observed in 6 cases (60%) and moderate in 3 (30%). In conclusion, pyrazinamide-associated DILI required prolonged hospital stay, presented jaundice in little more than a third of the cases, and radiologically, the hepatocellular pattern predominated.

Título traducido de la contribuciónClinical characteristics of pyrazinamide-associated hepatotoxicity in patients at a hospital in lima, peru
Idioma originalEspañol
Páginas (desde-hasta)516-520
Número de páginas5
PublicaciónRevista Peruana de Medicina de Experimental y Salud Publica
Volumen37
N.º3
DOI
EstadoPublicada - 1 jul. 2020

Nota bibliográfica

Publisher Copyright:
© 2020, Instituto Nacional de Salud. All rights reserved.

Palabras clave

  • Adverse Drug Reaction
  • Antituberculosis Drugs
  • Drug Induced Liver Injury
  • Length of Stay. (Source: MeSH NLM)
  • Pyrazinamide
  • Tuberculosis

Huella

Profundice en los temas de investigación de 'Características clínicas de la hepatotoxicidad asociada a la pirazinamida en pacientes de un hospital de lima, perú'. En conjunto forman una huella única.

Citar esto