Purpose: To compare the effect of eye rubbing on Scheimpflug imaging parameters and corneal biomechanics in eyes with keratoconus and healthy eyes. Setting: Oftalmosalud Instituto de Ojos, Lima, Peru. Design: Prospective cohort study. Methods: The study included healthy and keratoconus patients who attended the institution between January 2017 and July 2017. Eye rubbing was performed for 1 minute followed by a 5-second break, followed by further rubbing for 1 minute. Baseline tests were performed before rubbing; post-rubbing tests were performed immediately after (0 minutes), and then again at 7 minutes and 14 minutes. Parameters related to anterior and posterior curvature and elevation, pachymetry, and corneal biomechanics obtained from tomography with a rotating Scheimpflug camera (Pentacam HR) and a dynamic bidirectional applanation device (Ocular Response Analyzer) were measured and compared between healthy and keratoconic eyes. Results: The study included 30 healthy eyes and 31 keratoconic eyes. In the healthy group, the immediate mean changes in steeper anterior keratometry, posterior astigmatism, anterior chamber volume (ACV), flattest posterior keratometry, and Goldmann-correlated intraocular pressure (IOPg) after eye rubbing were 0.07 diopters (D) ± 0.15 (SD), –0.01 ± 0.08 D, 0.03 ± 7.06 mm3, −0.001 ± 0.04 mm, and −1.21 ± 1.99 mm Hg, respectively, whereas the mean changes in the keratoconus group were −0.03 ± 0.32 D, 0.14 ± 0.50 D, −5.09 ± 8.45 mm3, 0.03 ± 0.06 mm, and –1.61 ± 1.41 mm Hg, respectively. There were statistically significant differences between the preoperative and postoperative eye-rubbing values of posterior astigmatism, ACV, and IOPg in the keratoconus group (P = .03, P = .0003, and P = .001, respectively) but not in the healthy group (P = .65, P = .85, and P = .23, respectively). Conclusions: Unlike the healthy eyes group, the keratoconus group experienced significant changes in ACV, IOP, and corneal posterior astigmatism after eye rubbing.
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