Asociación del polimorfismo genético de la interleucina-1beta con periodontitis crónica en adultos peruanos

Ivonne Fanny Reyes-Mandujano, José E. Olivera-García, Manuel Taboada-Vega, Patricia Galvan-Sanchez, Amilcar Azcarza-Acuña, Aldo M. Yactayo-Flores, Luis A. Zuñiga-Ccoicca, Evelyn V. Leiva-Pachas, Efraín Paccori-García

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Objectives. To determine the connection between polymorphism IL-1B C(+3953/4)T and chronic periodontitis in adults. Materials and Methods. Case and control study. Individuals between 18 and 64 years of age were included; they were recruited through healthcare campaigns carried out in 2012 in different areas of the city of Lima with similar socio-economic characteristics. Dentists specialized in periodontics performed the diagnosis of the periodontal state of participants; genotyping was made through the PCR-RFLP technique. The data were analyzed by logistic regression. Results. The factors associated with chronic periodontitis were: age over 46 years (OR: 7.50, CI 95%: 1.85-6.37), higher education level achieved (OR: 0.43, CI 95%: 0.27-0.98), the presence of allele 2 in the polymorphism of IL-1B. The positive genotype (2-2) was associated with the presence of chronic periodontitis (OR: 2.06, CI 95%: 1.01-4.21). Conclusions. The presence of allele 2 in the polymorphism of IL-1B and the positive genotype (2-2) confers greater risk for the development of chronic periodontitis in the population of Peruvian adults under study.

Título traducido de la contribuciónConnection between genetic polymorphism of interleukin-1beta with chronic periodontitis in Peruvian adults
Idioma originalEspañol
Páginas (desde-hasta)9-14
Número de páginas6
PublicaciónRevista Peruana de Medicina de Experimental y Salud Publica
Volumen35
N.º1
DOI
EstadoPublicada - 1 ene 2018

Nota bibliográfica

Publisher Copyright:
© 2018, Instituto Nacional de Salud. All rights reserved.

Palabras clave

  • Chronic periodontitis
  • Cytokines
  • Genetic polymorphism
  • Polymerase chain reaction

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