Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru

Zhiyong Zhou, Sean M. Griffing, Alexandre Macedo De Oliveira, Andrea M. McCollum, Wilmer Marquino Quezada, Nancy Arrospide, Ananias A. Escalante, Venkatachalam Udhayakumar

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

41 Citas (Scopus)

Resumen

The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin.

Idioma originalInglés
Páginas (desde-hasta)739-741
Número de páginas3
PublicaciónAntimicrobial Agents and Chemotherapy
Volumen52
N.º2
DOI
EstadoPublicada - feb 2008

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