TY - JOUR
T1 - Differences in clinical manifestations among Cryptosporidium species and subtypes in HIV-infected persons
AU - Cama, Vitaliano A.
AU - Ross, Jennifer M.
AU - Crawford, Sara
AU - Kawai, Vivian
AU - Chavez-Valdez, Raul
AU - Vargas, Daniel
AU - Vivar, Aldo
AU - Ticona, Eduardo
AU - Ñavincopa, Marco
AU - Williamson, John
AU - Ortega, Ynes
AU - Gilman, Robert H.
AU - Bern, Caryn
AU - Xiao, Lihua
N1 - Funding Information:
Financial support: Opportunistic Infections Working Group of the Centers for Disease Control and Prevention (CDC); RG-ER Fund; National Institute for Allergy and Infectious Disease, National Institutes of Health (projects 5P01AI051976-04 and 5R21AI059661-02 to R.H.G. and V.A.C.); Division of Parasitic Diseases, CDC (Research Participation Program appointment to S.C. administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and the CDC).
PY - 2007/9/1
Y1 - 2007/9/1
N2 - We performed a cross-sectional study to determine the epidemiology of Cryptosporidium in human immunodeficiency virus (HIV)-infected persons at 3 diagnostic levels: microscopy, genotypes of Cryptosporidium, and subtype families of C. hominis and C. parvum. The study enrolled 2490 HIV-infected persons in Lima, Peru, and 230 were microscopy positive for Cryptosporidium infection. Specimens from 193 participants were available for genotyping. They had C. hominis (141 persons), C. parvum (22 persons), C. meleagridis (17 persons), C. canis (6 persons), C. felis (6 persons), and C. suis (1 person) infection. Although microscopy results showed that Cryptosporidium infections were associated with diarrhea, only infections with C. canis, C. felis, and subtype family Id of C. hominis were associated with diarrhea, and infection with C. parvum was associated with chronic diarrhea and vomiting. These results demonstrate that different Cryptosporidium genotypes and subtype families are linked to different clinical manifestations.
AB - We performed a cross-sectional study to determine the epidemiology of Cryptosporidium in human immunodeficiency virus (HIV)-infected persons at 3 diagnostic levels: microscopy, genotypes of Cryptosporidium, and subtype families of C. hominis and C. parvum. The study enrolled 2490 HIV-infected persons in Lima, Peru, and 230 were microscopy positive for Cryptosporidium infection. Specimens from 193 participants were available for genotyping. They had C. hominis (141 persons), C. parvum (22 persons), C. meleagridis (17 persons), C. canis (6 persons), C. felis (6 persons), and C. suis (1 person) infection. Although microscopy results showed that Cryptosporidium infections were associated with diarrhea, only infections with C. canis, C. felis, and subtype family Id of C. hominis were associated with diarrhea, and infection with C. parvum was associated with chronic diarrhea and vomiting. These results demonstrate that different Cryptosporidium genotypes and subtype families are linked to different clinical manifestations.
UR - http://www.scopus.com/inward/record.url?scp=34548068303&partnerID=8YFLogxK
U2 - 10.1086/519842
DO - 10.1086/519842
M3 - Artículo
C2 - 17674309
AN - SCOPUS:34548068303
SN - 0022-1899
VL - 196
SP - 684
EP - 691
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -