Dual Effects of Resveratrol on Cell Death and Proliferation of Colon Cancer Cells

Álvaro San Hipólito-Luengo, Antonio Alcaide, Mariella Ramos-González, Elena Cercas, Susana Vallejo, Alejandra Romero, Elena Talero, Carlos F. Sánchez-Ferrer, Virginia Motilva, Concepción Peiró

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

18 Citas (Scopus)

Resumen

Colorectal cancer remains a main cause of deaths worldwide, and novel agents are being searched to treat this disease. Polyphenols have emerged as promising therapeutic tools in cancer. Resveratrol (3,5,4′-trihydoxy-trans-stilbene) induces cell death in different tumor cell lines, and it also stimulates the proliferation of specific breast and prostate cancer cell lines. Here, we studied the impact of resveratrol over a 100-fold concentration range on cell death and proliferation of HT-29 colorectal adenocarcinoma cells. After 96 h of treatment, a biphasic pattern was observed. At lower concentrations (1 and 10 μmol/l), resveratrol increased the cell number, as did the polyphenol quercetin. At 50 or 100 μmol/l, resveratrol reduced the cell number and increased the percentage of apoptotic or necrotic cells, thus indicating cytotoxicity. On HCT116 colon cancer cells, however, no proliferative properties of resveratrol were observed. Resveratrol-induced cytotoxicity on HT-29 cells was associated with NADPH oxidase activation and increased levels of histone γH2AX, a marker of DNA damage, paralleled by enhanced sirtuin 6 levels, likely as a repair mechanism. Overall, resveratrol may be an effective tool in anti-tumor chemotherapy. However, since under some conditions it may favor tumor cell growth, appropriate local concentrations must be achieved to minimize unwanted effects of resveratrol.

Idioma originalInglés
Páginas (desde-hasta)1019-1027
Número de páginas9
PublicaciónNutrition and Cancer
Volumen69
N.º7
DOI
EstadoPublicada - 3 oct 2017

Nota bibliográfica

Publisher Copyright:
© 2017 Taylor & Francis Group, LLC.

Huella

Profundice en los temas de investigación de 'Dual Effects of Resveratrol on Cell Death and Proliferation of Colon Cancer Cells'. En conjunto forman una huella única.

Citar esto