TY - JOUR
T1 - EBV-positive diffuse large B-cell lymphoma in a human T-lymphotropic virus type 1 carrier
AU - Beltran, Brady
AU - Salas, Renzo
AU - Quĩones, Pilar
AU - Morales, Domingo
AU - Hurtado, Fernando
AU - Cotrina, Esther
AU - Riva, Luis
AU - Castillo, Jorge
PY - 2009
Y1 - 2009
N2 - The development of B-cell lymphomas has been seldom described in HTLV-1 carriers. We present the case of an elderly Peruvian HTLV-1 carrier who was diagnosed with EBV-positive diffuse large B-cell lymphoma. Despite an initial good response to therapy, patient died during treatment due to fatal Pneumocystis jirovecci pneumonia. EBV infection is characterized by B-cell lymphotropism and selective immunodeficiency. HTLV-1, on the other hand, induces T-cell dysfunction and B-cell proliferation. Finally, immunosenescence is characterized by T-cell dysregulation, decreased apoptosis and cytokine upregulation. In this elderly patient, the combination of EBV and HTLV-1 coinfection and immunosenescence may have played a role in the development of this aggressive diffuse large B-cell lymphoma. Furthermore, the immunodeficiency caused by the viral infections and chemotherapy may have played a role in developing life-threatening infectious complications.
AB - The development of B-cell lymphomas has been seldom described in HTLV-1 carriers. We present the case of an elderly Peruvian HTLV-1 carrier who was diagnosed with EBV-positive diffuse large B-cell lymphoma. Despite an initial good response to therapy, patient died during treatment due to fatal Pneumocystis jirovecci pneumonia. EBV infection is characterized by B-cell lymphotropism and selective immunodeficiency. HTLV-1, on the other hand, induces T-cell dysfunction and B-cell proliferation. Finally, immunosenescence is characterized by T-cell dysregulation, decreased apoptosis and cytokine upregulation. In this elderly patient, the combination of EBV and HTLV-1 coinfection and immunosenescence may have played a role in the development of this aggressive diffuse large B-cell lymphoma. Furthermore, the immunodeficiency caused by the viral infections and chemotherapy may have played a role in developing life-threatening infectious complications.
UR - http://www.scopus.com/inward/record.url?scp=68149175122&partnerID=8YFLogxK
U2 - 10.1186/1750-9378-4-10
DO - 10.1186/1750-9378-4-10
M3 - Artículo
AN - SCOPUS:68149175122
SN - 1750-9378
VL - 4
JO - Infectious Agents and Cancer
JF - Infectious Agents and Cancer
IS - 1
M1 - 10
ER -