© 2019 Universidad Nacional Mayor de San Marcos. All rights reserved. The present study evaluated the effect of the inclusion of probiotic, prebiotic and the combination of both (symbiotic) in the diet on the productive parameters of Guinea pigs (Cavia porcellus). Fifty 3-day-old male Guinea pigs were selected from a Prolific-Dairy maternal line developed in the IVITA-El Mantaro Research Station (Peru) and randomly distributed in five treatments consisting of a basal diet of forages (rye-grass and red clover). supplemented with wheat bran (T5), plus probiotic (T1), prebiotic (T2), symbiotic (T3) and antibiotic growth-promoter (AGP) (T4). The probiotic was a mixture of six bacterial species isolated from the intestine and Guinea pig faeces; the prebiotic was a commercial mannanoligosaccharide and the APC was Zn-bacitracin. The response to treatments was evaluated for 56 days in terms of body weight gain, feed intake and feed conversion ratio. No significant or consistent responses were observed as effect of the treatments. The lack of response to AGP and the good body weight gains obtained suggested that, under the conditions of the study, the intestinal microbial balance of the animals was appropriate.