Efecto de los AINEs y la presión de oxígeno ambiental sobre la regeneración ósea

Victor Chumpitaz-Cerrate, Lesly Chávez-Rimache, César Franco-Quino, Elías Aguirre-Siancas, Victoria Caldas-Cueva, Eliberto Ruíz-Ramírez

Resultado de la investigación: Contribución a una revistaArtículorevisión exhaustiva

Resumen

Objective: To evaluate the effects of administering diclofenac and ketoprofen, as well as the effects of environmental oxygen pressure variation on mandibular bone regeneration. Methods: Thirty-six guinea pigs were distributed into two equal groups. Mandibular bone defects were performed on both groups. Group A was monitored under oxygen pressure at altitude (3320msl, 107mm Hg). Group B was monitored at sea level oxygen pressure (150msl, 157mm Hg). Each group was subdivided into 3 equal groups (A1, A2, A3 and B1, B2, B3). Subgroups A1 and B1 were given diclofenac; subgroups A2 and B2 ketoprofen; subgroups A3 and B3 NaCl. Bone regeneration was evaluated histologically on days 15 and 30. Results: After 15 days in the group controlled at sea level, the level of osteoblasts presented by the control subgroup was significantly higher (28.00±2.65) compared to the diclofenac subgroup (16.00±6.25) and to the ketoprofen subgroup (18.00±4.36); (p=0.041). After 15 days in the group controlled at altitude, the level of osteoblasts was significantly higher in the control subgroup (38.00±5.29) compared to the diclofenac subgroup (21.67±6.35) and to the ketoprofen subgroup (19.33±2.52); p=0.007. After 30 days in the group at sea level there was no difference found in the cell counting; p>0.05. After 30 days in the group controlled at altitude, the level of osteoblast was significantly higher in the control subgroup (58.00±4.58) compared to the diclofenac subgroup (34.33±4.73) and the ketoprofen subgroup (34.00±11.14); (p=0.003). Conclusion: The administration of diclofenac and ketoprofen produced lower mandibular bone regeneration, the effect being significantly more negative at sea level.

Título traducido de la contribuciónEffects of nsaids and environmental oxygen pressure on bone regeneration
Idioma originalEspañol
Páginas (desde-hasta)152-158
Número de páginas7
PublicaciónJournal of Oral Research
Volumen8
N.º2
DOI
EstadoPublicada - 1 abr 2019

Nota bibliográfica

Publisher Copyright:
© 2019, Universidad de Concepcion. All rights reserved.

Palabras clave

  • Anti-Inflammatory agents
  • Atmospheric pressure
  • Bone Regeneration
  • Hypoxia
  • Hypoxia-inducible factor 1
  • Non-steroidal

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