Encefalitis autoinmune mediada por anticuerpos contra el receptor n-metil-d-aspartato: Reporte de cuatro casos en Perú

Henry Palomino-Lescano, Darwin Segura-Chávez, Darko Quispe-Orozco, Sheila Castro-Suarez, Walter De la Cruz, Willy Zapata-Luyo, José Delgado-Ríos, Juan Cam, Marcela Alvarado-Morales, Lippmann Paredes-Carcasi, Iván Cornejo-Herrera, María Meza-Vega

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

2 Citas (Scopus)

Resumen

Autoimmune encephalitis with antibodies against the N-methyl-D-aspartate receptor (anti-NMDAR) is a disorder mediated by antibodies against neural surface antigens, whose early diagnosis and timely treatment improve the prognosis of the disease. Four cases with the definitive diagnosis of autoimmune encephalitis by anti-NMDAR are presented, treated at the National Institute of Neurological Sciences in Lima-Peru. All patients had epileptic seizures and three cases developed a refractory epileptic state. In addition, three patients presented neuropsychiatric alterations, dyskinesias, and dysautonomia. Two cases required ventilatory support. All presented an abnormal electroencephalogram; two cases had pleocytosis in cerebrospinal fluid, and only one showed brain abnormalities on MRI. Regarding treatment, all patients received methylprednisolone immunotherapy and only two of them required plasma exchange for an ineffective response to corticosteroid treatment. After 12 months of hospital discharge, three patients were free of epileptic seizures and only one case did not achieve functional independence. These cases show that anti-NMDAR encephalitis is a treatable condition and its early recognition together with appropriate treatment (immunotherapy/plasmapheresis) are essential for a favorable evolution.

Título traducido de la contribuciónAutoimmune encephalitis mediated by antibodies against the n-methyl-d-aspartate receptor: Report of four cases in Peru
Idioma originalEspañol
Páginas (desde-hasta)138-144
Número de páginas7
PublicaciónRevista Peruana de Medicina de Experimental y Salud Publica
Volumen36
N.º1
DOI
EstadoPublicada - mar. 2019

Nota bibliográfica

Publisher Copyright:
© 2019, Instituto Nacional de Salud. All rights reserved.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Palabras clave

  • Case reports
  • N-methyl-d-aspartate antirreceptor encephalitis
  • Peru

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