TY - JOUR
T1 - Endemic Venezuelan Equine Encephalitis in Northern Peru
AU - Aguilar, Patricia V.
AU - Greene, Ivorlyne P.
AU - Coffey, Lark L.
AU - Medina, Gladys
AU - Moncayo, Abelardo C.
AU - Anishchenko, Michael
AU - Ludwig, George V.
AU - Turell, Michael J.
AU - O'Guinn, Monica L.
AU - Lee, John
AU - Tesh, Robert B.
AU - Watts, Douglas M.
AU - Russell, Kevin L.
AU - Hice, Christine
AU - Yanoviak, Stephen
AU - Morrison, Amy C.
AU - Klein, Terry A.
AU - Dohm, David J.
AU - Guzman, Hilda
AU - Travassos Da Rosa, Amelia P.A.
AU - Guevara, Carolina
AU - Kochel, Tadeusz
AU - Olson, James
AU - Cabezas, Cesar
AU - Weaver, Scott C.
PY - 2004/5
Y1 - 2004/5
N2 - Since Venezuelan equine encephalitis virus (VEEV) was isolated in Peru in 1942, >70 isolates have been obtained from mosquitoes, humans, and sylvatic mammals primarily in the Amazon region. To investigate genetic relationships among the Peru VEEV isolates and between the Peru isolates and other VEEV strains, a fragment of the PE2 gene was amplified and analyzed by single-stranded conformation polymorphism. Representatives of seven genotypes underwent sequencing and phylogenetic analysis. The results identified four VEE complex lineages that cocirculate in the Amazon region: subtypes ID (Panama and Colombia/Venezuela genotypes), IIIC, and a new, proposed subtype IIID, which was isolated from a febrile human, mosquitoes, and spiny rats. Both ID lineages and the IIID subtype are associated with febrile human illness. Most of the subtype ID isolates belonged to the Panama genotype, but the Colombia/Venezuela genotype, which is phylogenetically related to epizootic strains, also continues to circulate in the Amazon basin.
AB - Since Venezuelan equine encephalitis virus (VEEV) was isolated in Peru in 1942, >70 isolates have been obtained from mosquitoes, humans, and sylvatic mammals primarily in the Amazon region. To investigate genetic relationships among the Peru VEEV isolates and between the Peru isolates and other VEEV strains, a fragment of the PE2 gene was amplified and analyzed by single-stranded conformation polymorphism. Representatives of seven genotypes underwent sequencing and phylogenetic analysis. The results identified four VEE complex lineages that cocirculate in the Amazon region: subtypes ID (Panama and Colombia/Venezuela genotypes), IIIC, and a new, proposed subtype IIID, which was isolated from a febrile human, mosquitoes, and spiny rats. Both ID lineages and the IIID subtype are associated with febrile human illness. Most of the subtype ID isolates belonged to the Panama genotype, but the Colombia/Venezuela genotype, which is phylogenetically related to epizootic strains, also continues to circulate in the Amazon basin.
UR - http://www.scopus.com/inward/record.url?scp=11144354917&partnerID=8YFLogxK
U2 - 10.3201/eid1005.030634
DO - 10.3201/eid1005.030634
M3 - Artículo
C2 - 15200823
AN - SCOPUS:11144354917
SN - 1080-6040
VL - 10
SP - 880
EP - 888
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 5
ER -