TY - JOUR
T1 - Evaluation of nitazoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep
AU - Gavidia, Cesar M.
AU - Gonzalez, Armando E.
AU - Lopera, Luis
AU - Jayashi, Cesar
AU - Angelats, Roxana
AU - Barron, Eduardo A.
AU - Ninaquispe, Berenice
AU - Villarreal, Lucia
AU - Garcia, Hector H.
AU - Verastegui, Manuela R.
AU - Gilman, Robert H.
PY - 2009/3/1
Y1 - 2009/3/1
N2 - Cystic echinococosis (CE) is a public health problem caused by Echinococcus granulosus. We aimed to determine the efficacy of nitazoxanide (NTZ) and oxfendazole (OXF) against CE in naturally infected sheep. A total of 151 ewes were assigned to the following groups: 15 mg/kg of NTZ weekly for five weeks (NTZ5); two rounds of 15 mg/ kg of NTZ a day for five days (NTZ5×2) two weeks apart; 30 mg/kg of OXF a week for 11 weeks (OXF11); 30 mg/kg of OXF plus 15 mg/kg of NTZ a week for 11 weeks (OXF/NTZ); and the control group. OXF11 and OXF/NTZ decreased the number of fertile cysts, increased the number of degenerated cysts, and were more efficacious (49.6-61.2%) against lung cysts and liver cysts (91.8-100%) than any other treatment group. OXF might be an additional strategy for control programs and an optional treatment of human CE after it is licensed. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
AB - Cystic echinococosis (CE) is a public health problem caused by Echinococcus granulosus. We aimed to determine the efficacy of nitazoxanide (NTZ) and oxfendazole (OXF) against CE in naturally infected sheep. A total of 151 ewes were assigned to the following groups: 15 mg/kg of NTZ weekly for five weeks (NTZ5); two rounds of 15 mg/ kg of NTZ a day for five days (NTZ5×2) two weeks apart; 30 mg/kg of OXF a week for 11 weeks (OXF11); 30 mg/kg of OXF plus 15 mg/kg of NTZ a week for 11 weeks (OXF/NTZ); and the control group. OXF11 and OXF/NTZ decreased the number of fertile cysts, increased the number of degenerated cysts, and were more efficacious (49.6-61.2%) against lung cysts and liver cysts (91.8-100%) than any other treatment group. OXF might be an additional strategy for control programs and an optional treatment of human CE after it is licensed. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
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M3 - Article
SN - 0002-9637
SP - 367
EP - 372
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
ER -
