Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro

A. Santa Maria; A. Lopez; M. M. Diaz; J. Albán; A. Galán De Mera; J. A. Vicente Orellana; J. M. Pozuelo

doi:10.1016/S0378-8741(97)00067-6

Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro

A. Santa Maria, A. Lopez, M. M. Diaz, J. Albán, A. Galán De Mera, J. A. Vicente Orellana, J. M. Pozuelo

Resultado de la investigación: Contribución a una revista › Artículo › revisión exhaustiva

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Resumen

Aqueous extracts of Uncaria tomentosa (Willdenow ex Roemer and Shultes) DC. (Rubiaceae) ('Una de gato'), were analyzed for the presence of toxic compounds in Chinese hamster ovary cells (CHO) and bacterial cells (Photobacterium phosphoreum). Toxicity was evaluated by four systems: Neutral red assay (NR), total protein content (KB), tetrazolium assay (MTT) and Microtox test. The extracts of U. tomentosa did not show toxicity in vitro at the concentrations tested. Testing in vitro could be a valuable tool for evaluating toxicity of medicinal plants.

Idioma original	Inglés estadounidense
Páginas (desde-hasta)	183-187
Número de páginas	5
Publicación	Journal of Ethnopharmacology
DOI	https://doi.org/10.1016/S0378-8741(97)00067-6
Estado	Publicada - 1 ago. 1997

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title = "Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro",

abstract = "Aqueous extracts of Uncaria tomentosa (Willdenow ex Roemer and Shultes) DC. (Rubiaceae) ('Una de gato'), were analyzed for the presence of toxic compounds in Chinese hamster ovary cells (CHO) and bacterial cells (Photobacterium phosphoreum). Toxicity was evaluated by four systems: Neutral red assay (NR), total protein content (KB), tetrazolium assay (MTT) and Microtox test. The extracts of U. tomentosa did not show toxicity in vitro at the concentrations tested. Testing in vitro could be a valuable tool for evaluating toxicity of medicinal plants.",

author = "{Santa Maria}, A. and A. Lopez and Diaz, {M. M.} and J. Alb{\'a}n and {Gal{\'a}n De Mera}, A. and {Vicente Orellana}, {J. A.} and Pozuelo, {J. M.}",

year = "1997",

month = aug,

day = "1",

doi = "10.1016/S0378-8741(97)00067-6",

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T1 - Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro

AU - Santa Maria, A.

AU - Lopez, A.

AU - Diaz, M. M.

AU - Albán, J.

AU - Galán De Mera, A.

AU - Vicente Orellana, J. A.

AU - Pozuelo, J. M.

PY - 1997/8/1

Y1 - 1997/8/1

N2 - Aqueous extracts of Uncaria tomentosa (Willdenow ex Roemer and Shultes) DC. (Rubiaceae) ('Una de gato'), were analyzed for the presence of toxic compounds in Chinese hamster ovary cells (CHO) and bacterial cells (Photobacterium phosphoreum). Toxicity was evaluated by four systems: Neutral red assay (NR), total protein content (KB), tetrazolium assay (MTT) and Microtox test. The extracts of U. tomentosa did not show toxicity in vitro at the concentrations tested. Testing in vitro could be a valuable tool for evaluating toxicity of medicinal plants.

AB - Aqueous extracts of Uncaria tomentosa (Willdenow ex Roemer and Shultes) DC. (Rubiaceae) ('Una de gato'), were analyzed for the presence of toxic compounds in Chinese hamster ovary cells (CHO) and bacterial cells (Photobacterium phosphoreum). Toxicity was evaluated by four systems: Neutral red assay (NR), total protein content (KB), tetrazolium assay (MTT) and Microtox test. The extracts of U. tomentosa did not show toxicity in vitro at the concentrations tested. Testing in vitro could be a valuable tool for evaluating toxicity of medicinal plants.

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JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

ER -

Evaluation of the toxicity of Uncaria tomentosa by bioassays in vitro

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