Explaining urokinase type plasminogen activator inhibition by amino-5-hydroxybenzimidazole and two naphthamidine-based compounds through quantum biochemistry

Keyphrases

• Urokinase-type Plasminogen Activator 100%
• Quantum Biochemistry 100%
• Amino 100%
• Inhibitory Compounds 16%
• Amino Acid Residues 16%
• Main Determinants 16%
• Density Functional Theory 16%
• Therapeutic Target 16%
• Cancer Treatment 16%
• Crystallographic Data 16%
• Interaction Energy 16%
• Plasminogen Activator inhibitor-1 (PAI-1) 16%
• Interacting Amino Acids 16%
• Tumor Metastasis 16%
• Energy Interaction 16%
• Energy Contribution 16%
• 2-Aminopyrimidine 16%
• New Medicines 16%
• Tumor Growth 16%
• Protonation State 16%
• Total Energy 16%
• Cancer Types 16%
• Molecular Fractionation 16%
• Binding Mechanism 16%

Chemistry

• % Inhibition 100%
• Fractionation 50%
• Density Functional Theory 50%
• Plasminogen Activator Inhibitor 50%
• Aminopyrimidine 50%
• Amino-Acid Residue 50%
• Biological Marker 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Urokinase 100%
• Malignant Neoplasm 33%
• Interaction Energy 33%
• Amino Acid 16%
• Biological Marker 16%
• Tumor Growth 16%
• Metastasis 16%
• Plasminogen Activator Inhibitor 16%