Cymatium (Monoplex) keenae Beu, 1970, the neopolitan triton, is a Ranellidae predator distributed in tropical and subtropical waters. In this study we report this species for the first time in Antofagasta Bay, northern Chile. Adult specimens have been found since June 2003 at depths ranging from 5 to 15 m in La Rinconada Marine Reserve (23°28′18″S, 70°30′46″W) in Antofagasta Bay, near a scallop farming facility. The present findings clearly extend the geographic range of C. keenae, which previously had been reported from La Paz, Gulf of California (Mexico) to Galápagos Islands (Ecuador) in the SE Pacific. Previous evidence strongly suggests that the intrusion of this tropical immigrant can be related to warm El Niño episodes. We analyze the key role of the oceanographic characteristics of Antofagasta Bay as potential temporal refuge for this species.